Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral Vector Aedes albopictus

Frontiers in Genetics
Elisa PischeddaMariangela Bonizzoni

Abstract

The Asian tiger mosquito Aedes albopictus is an invasive mosquito and a competent vector for public-health relevant arboviruses such as Chikungunya (Alphavirus), Dengue and Zika (Flavivirus) viruses. Unexpectedly, the sequencing of the genome of this mosquito revealed an unusually high number of integrated sequences with similarities to non-retroviral RNA viruses of the Flavivirus and Rhabdovirus genera. These Non-retroviral Integrated RNA Virus Sequences (NIRVS) are enriched in piRNA clusters and coding sequences and have been proposed to constitute novel mosquito immune factors. However, given the abundance of NIRVS and their variable viral origin, their relative biological roles remain unexplored. Here we used an analytical approach that intersects computational, evolutionary and molecular methods to study the genomic landscape of mosquito NIRVS. We demonstrate that NIRVS are differentially distributed across mosquito genomes, with a core set of seemingly the oldest integrations with similarity to Rhabdoviruses. Additionally, we compare the polymorphisms of NIRVS with respect to that of fast and slow-evolving genes within the Ae. albopictus genome. Overall, NIRVS appear to be less polymorphic than slow-evolving genes, with d...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Genetics·Jeffrey R Powell
Aug 28, 2020·Genome Biology·Umberto PalatiniMariangela Bonizzoni
Aug 31, 2019·Emerging Microbes & Infections·Vincent HouéAnna-Bella Failloux
Nov 5, 2019·Trends in Immunology·Youdiil OphinniNicholas F Parrish
Nov 7, 2021·Current Opinion in Insect Science·Umberto PalatiniMariangela Bonizzoni

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Datasets Mentioned

BETA
AALF004102
AALF018679
AALF024551
AALF005498
AALF004130
AALF025780

Methods Mentioned

BETA
PCR

Software Mentioned

GATK
PER
Vardict
Vy
Ugene
qbase +
GATK UnifiedGenotyper
Freebayes
OrthoDB
MAFFT

Related Concepts