Aug 11, 2019

Insights into anti-pathogenic activities of mannose lectins

International Journal of Biological Macromolecules
Priscila Marcelino Dos Santos SilvaLuana Cassandra Breitenbach Barroso Coelho

Abstract

Carbohydrate-binding proteins, also known as lectins, are valuable tools for biotechnology, including pharmacological uses. Mannose lectins obtained from plant and animal sources are applied to protection and characterization of autoimmune diseases as well as defense proteins against pathogens. The presence of mannose-binding lectins in plants that also recognize glucose could be entitled Man/Glc lectins; such specificity has allowed employing these vegetal lectins for several applications. Animal mannose-binding lectins are synthesized in the liver and secreted into the blood stream where both concentration and activity are greatly affected due to gene polymorphisms; these serum proteins play important roles in the immune system by recognizing mannose-like carbohydrate ligands found exclusively on pathogenic microorganisms. Mannose lectins already showed strong binding to relevant bacteria, viruses, protozoa and helminth species, initiating potent host defense mechanisms by inducing growth inhibition or death of such organisms; the ability to prevent the formation or destruction of microbial biofilms has also been reported. Mannose-binding lectins have attracted considerable attention against carcinogenesis and atherogenesis. ...Continue Reading

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Mentioned in this Paper

Gene Polymorphism
Virus
Defense Mechanisms
Cessation of Life
Inhibition of Growth
Atherogenesis
LMAN2 protein, human
Protozoa
Glucose
Autoimmune Diseases

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