Insights into Body Size Evolution: A Comparative Transcriptome Study on Three Species of Asian Sisoridae Catfish

International Journal of Molecular Sciences
Wansheng JiangJunxing Yang

Abstract

Body size is one of the most important attributes of a species, but the basic question of why and how each species reaches a different "right size" is still largely unknown. Herein, three phylogenetically closely related catfishes from Sisoridae, including one extraordinarily large-sized Bagarius yarrelli and two average-sized Glyptothorax macromaculatus and Oreoglanis setiger, were comparatively studied using RNA-Seq. Approximately 17,000 protein-coding genes were annotated for each of the three fishes, and 9509 genes were identified as high-confidence orthologous gene pairs. Comparative expressions uncovered a similar functional cluster about ribosome biogenesis was enriched in different tissues of the upregulated genes of Bagarius yarrelli. Moreover, differentially expressed genes and positively selected genes revealed that the glycolysis/pyruvate metabolism and cell cycle pathways have also greatly enhanced in this large-sized species. In total, 20 size-related candidate genes (including two growth modulators: the serine/threonine-protein kinases 3 (AKT3) and adaptor protein 1 (SH2B1), and a crucial pyruvate kinase (PKM2A)) were identified by multiplying comparative analyses along with gene functional screening, which would...Continue Reading

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Citations

Jul 6, 2019·Genome Biology and Evolution·Wansheng JiangQiong Shi

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Methods Mentioned

BETA
RNA-Seq
GTPase
electrophoresis
PCR

Software Mentioned

PAML4
Trinity
BLAST +
MEGA7
MODELLER
Bowtie2
codeml
DAVID
Trinotate
Web Gene Ontology Annotation Plot WEGO

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