Insights into Chimeric Antigen Receptor Therapy for Chronic Lymphoblastic Leukemia

Trends in Molecular Medicine
Mohamad Hamieh, Michel Sadelain

Abstract

In a recent study, Fraietta and colleagues identified chimeric antigen receptor (CAR) T cell biomarkers that may predict the success or failure of CAR therapy in patients with refractory chronic lymphoblastic leukemia (CLL). These findings open new prospects for improving T cell product manufacturing and the management of patients with CLL undergoing T cell-based therapies.

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