Insights into Cobalta(III/IV/II)-Electrocatalysis: Oxidation-Induced Reductive Elimination for Twofold C-H Activation

Angewandte Chemie
Tjark H MeyerLutz Ackermann

Abstract

The merger of cobalt-catalyzed C-H activation and electrosynthesis provides new avenues for resource-economical molecular syntheses, unfortunately their reaction mechanisms remain poorly understood. Herein, we report the identification and full characterization of electrochemically generated high-valent cobalt(III/IV) complexes as crucial intermediates in electrochemical cobalt-catalyzed C-H oxygenations. Detailed mechanistic studies provided support for an oxidatively-induced reductive elimination via highly-reactive cobalt(IV) intermediates. These key insights set the stage for unprecedented cobaltaelectro two-fold C-H/C-H activation.

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Citations

Jan 21, 2021·Angewandte Chemie·Yulei WangLutz Ackermann
Feb 26, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yulia H Budnikova
Apr 2, 2021·ACS Central Science·Cuiju ZhuLutz Ackermann
Mar 20, 2021·Angewandte Chemie·Sara López-ResanoMónica H Pérez-Temprano
Mar 3, 2021·Angewandte Chemie·Xuefeng TanLutz Ackermann
May 25, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Ramesh C Samanta, Lutz Ackermann
Jun 15, 2021·Chemical Science·Ramesh C SamantaLutz Ackermann
Nov 5, 2021·Chemical Communications : Chem Comm·Janis Mikelis ZakisJoanna Wencel-Delord

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Methods Mentioned

BETA
NMR

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