Insights into epigenetic landscape of recombination-free regions

Chromosoma
Pasquale TermolinoClara Conicella

Abstract

Genome architecture is shaped by gene-rich and repeat-rich regions also known as euchromatin and heterochromatin, respectively. Under normal conditions, the repeat-containing regions undergo little or no meiotic crossover (CO) recombination. COs within repeats are risky for the genome integrity. Indeed, they can promote non-allelic homologous recombination (NAHR) resulting in deleterious genomic rearrangements associated with diseases in humans. The assembly of heterochromatin is driven by the combinatorial action of many factors including histones, their modifications, and DNA methylation. In this review, we discuss current knowledge dealing with the epigenetic signatures of the major repeat regions where COs are suppressed. Then we describe mutants for epiregulators of heterochromatin in different organisms to find out how chromatin structure influences the CO rate and distribution.

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·L O RossD Dawson
Jun 6, 1998·Genes & Development·L Maloisel, J L Rossignol
Jun 18, 2002·Current Opinion in Cell Biology·Monika Lachner, Thomas Jenuwein
Jun 22, 2002·Science·Anne-Valérie GendrelRobert A Martienssen
Oct 11, 2002·American Journal of Human Genetics·Christine J ShawJames R Lupski
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ira M HallShiv I S Grewal
Mar 2, 2005·PLoS Biology·Thomas Lenormand, Julien Dutheil
Mar 8, 2005·Nature Cell Biology·Susana GonzaloMaría A Blasco
Feb 14, 2006·Science·Michael Shogren-KnaakCraig L Peterson
Jul 29, 2006·Cell·Emmanuelle MartiniScott Keeney
Dec 16, 2006·Cellular and Molecular Life Sciences : CMLS·T MossV Stefanovsky
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Genetics·Thomas H Eickbush, Danna G Eickbush
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Piotr A MieczkowskiThomas D Petes
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Suzanne Furuyama, Sue Biggins
Jun 20, 2008·Genetics·Arnold B BartonDavid B Kaback
Jul 12, 2008·Annual Review of Cell and Developmental Biology·Brian McStay, Ingrid Grummt
Jul 12, 2008·PLoS Genetics·Kenneth PaigenPetko M Petkov
Jul 19, 2008·Cellular and Molecular Life Sciences : CMLS·S PisanoS Cacchione
Aug 12, 2008·Developmental Cell·Stacy Y ChenJennifer C Fung
Dec 17, 2008·The EMBO Journal·Valérie BordeAlain Nicolas
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Laurent Duret, Nicolas Galtier
Dec 3, 2009·Nature Reviews. Neuroscience·Yuka SasakiTakeo Watanabe
Feb 19, 2010·Nature Reviews. Molecular Cell Biology·Mariko SasakiScott Keeney
Mar 17, 2010·The Plant Journal : for Cell and Molecular Biology·Giorgio PerrellaClara Conicella
Mar 17, 2010·PLoS Biology·Paul B Talbert, Steven Henikoff
Mar 17, 2010·PLoS Biology·Jinghua ShiR Kelly Dawe
Apr 17, 2010·Science·Assaf ZemachDaniel Zilberman
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chad EllermeierGerald R Smith
Aug 3, 2010·Current Opinion in Cell Biology·Kaitlin M Stimpson, Beth A Sullivan
Oct 5, 2010·Current Genomics·Luke E Berchowitz, Gregory P Copenhaver

❮ Previous
Next ❯

Citations

Nov 8, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tyler V KentStephen I Wright
Mar 24, 2017·Molecular Biology and Evolution·Anastasia P KovinaSergey V Razin
Dec 15, 2019·Genes·Colleen J Lawrimore, Kerry Bloom
Sep 6, 2020·Experimental & Molecular Medicine·Jong-Hyuk LeeVilhelm A Bohr
Apr 14, 2019·Genome Biology and Evolution·James M HowieChristian Schlötterer
Feb 28, 2021·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Igor Costa AmorimRita de Cássia de Moura
Aug 22, 2021·Nucleic Acids Research·Ying WangLiangran Zhang
Jul 25, 2021·Journal of Experimental Botany·Dharmendra SinghMadan Pal
Oct 2, 2021·Molecular Biology and Evolution·Roven Rommel FuentesSander A Peters

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Reviews in Biochemistry and Molecular Biology
Carolyn M George, Eric Alani
BMC Genomics
Cinthya J Zepeda-MendozaRafael Palacios
Current Opinion in Genetics & Development
Jamy C Peng, Gary H Karpen
© 2022 Meta ULC. All rights reserved