Insights into gene therapy for critical limb ischemia: the devil is in the details

Vascular Pharmacology
Rosalinda Madonna, Gregg Rokosh

Abstract

Patients with critical limb ischemia (CLI) without potential for revascularization are currently without alternate therapies. Several gene therapy trials have tested angiogenesis factors, hepatic growth factor, vascular endothelial growth factor, and basic fibroblast growth factor, in rescuing CLI patients from amputation and mortality, and for improved quality of life including decreased pain, improved healing, and blood flow. Trial results have been variable, with HGF gene therapy being the most successful. New studies examining each of these angiogenic factors provide insights that will be useful for the design of effective therapeutic strategies.

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Citations

Apr 10, 2013·Vascular Pharmacology·Jeremy D Pearson
Apr 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laura Rose, Hasan Uludağ
Jun 21, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F VasuriG Pasquinelli
Sep 3, 2020·Journal of Cardiovascular Translational Research·Piotr BarćJan Paweł Skóra

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