Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

Hippocampus
John F Guzowski

Abstract

In the 14 years since it was discovered that specific genes could be dynamically regulated in the brain by neural activity, there has been a substantial research focus attempting to understand the role immediate-early genes (IEGs) play in various brain functions. This article examines the involvement of IEGs in hippocampal synaptic plasticity and in memory consolidation processes performed by the hippocampus. Studies employing conventional IEG detection methodologies and a novel gene-imaging approach that provides temporal and cellular resolution (cellular compartment analysis of emporal activity by fluorescence in situ hybridization or catFISH) provide evidence supporting the assertion that IEG expression reflects the integration of information processed by hippocampal neurons. However, IEG expression is not merely correlated with neural activity, but also plays a pivotal role in stabilizing recent changes in synaptic efficacy. As such, localized disruption of IEGs Arc or c-fos by intrahippocampal administration of antisense oligonucleotides or germline disruption of the IEGs c-fos, tissue plasminogen activator, or zif268 impairs consolidation of long-term memory formation, without affecting learning or short-term memory. Furt...Continue Reading

References

Nov 13, 1992·Cell·R S JohnsonV Papaioannou
Jun 1, 1992·Current Opinion in Cell Biology·L D KerrI M Verma
Jan 1, 1992·Progress in Nucleic Acid Research and Molecular Biology·M K Ghosh, J S Cohen
Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Jan 1, 1990·Progress in Brain Research·P F WorleyJ M Baraban
Sep 1, 1990·Behavioral and Neural Biology·W TischmeyerH Matthies
Jan 1, 1990·Progress in Growth Factor Research·Y A Barde
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B A ChristyD Nathans
Feb 1, 1987·Behavioral Neuroscience·P R RappM Gallagher
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·B W AgranoffJ J Brink
Apr 1, 1982·Physiology & Behavior·M E Judge, D Quartermain
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B MoserR G Morris
Jun 30, 1995·Annals of the New York Academy of Sciences·C M AlberiniE R Kandel
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·W LinkD Kuhl
Mar 1, 1994·Journal of Neurobiology·A GhoshM E Greenberg
Jul 18, 1994·Brain Research·R PaylorJ M Wehner
Feb 1, 1994·Trends in Pharmacological Sciences·C Wahlestedt
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·E HummlerG Schütz
Aug 20, 1993·Science·M A Wilson, B L McNaughton
Mar 1, 1993·Journal of Neuroscience Research·L Kaczmarek

❮ Previous
Next ❯

Citations

Jan 1, 2008·The Journal of Nutrition, Health & Aging·K L ViolaW L Klein
Aug 25, 2004·Neurotoxicity Research·Lionel Muller IgazJorge H Medina
Feb 3, 2011·Journal of Neurology·Francesco MoriDiego Centonze
Aug 7, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew G FoleyCiaran M Regan
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ainhoa BilbaoRainer Spanagel
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cynthia KatcheJorge H Medina
May 18, 2006·Learning & Memory·Kevin Bolding, Jerry W Rudy
Jun 17, 2004·Molecular and Cellular Biology·Jan Hendrik SitzBeat Lutz
Jul 16, 2011·Cancer Research·Munjal M AcharyaCharles L Limoli
Jun 4, 2005·BMC Neuroscience·Paul D EtterMani Ramaswami
Mar 21, 2008·PLoS Biology·Sarah C Woolley, Allison J Doupe
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie A Maddox, Glenn E Schafe
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ilse Delint-RamirezSeth G N Grant
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas L BeaumontJeffrey A Loeb
Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhihong JiangKazu Nakazawa
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gary T PhilipsThomas J Carew
Dec 1, 2011·Epigenomics·Rosemary E Puckett, Farah D Lubin
Apr 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yasunobu YasoshimaTakashi Yamamoto
Jul 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge J PalopLennart Mucke
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·John F GuzowskiCarol A Barnes
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Maria BeckerBeka Solomon
Mar 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah A SternCristina M Alberini
May 25, 2012·Journal of Neural Transmission·Sara LandgrenPetronella Kettunen
May 8, 2013·Behavioural Brain Research·Magdalena M SauvageZachery Beer
May 15, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Javier Cortés-MendozaLeonor Pérez-Martínez
Jan 22, 2003·Trends in Neurosciences·Karim Nader
Jan 19, 2010·Pharmacological Reports : PR·Bartosz Bobula, Grzegorz Hess

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