Insights into matrilineal genetic structure, differentiation and ancestry of Armenians based on complete mitogenome data

Molecular Genetics and Genomics : MGG
Miroslava DerenkoLevon Yepiskoposyan

Abstract

Distinctive peculiarities of Armenians such as their millennia-long genetic isolation and strong national identity attract a keen interest while studying the demographic history of the West Asia. Here, to examine their fine-scale matrilineal genetic structure, ancestry and relationships with neighboring populations, we analyzed 536 complete mitogenomes (141 of which are novel) from 8 geographically different Armenian populations, covering the whole stretch of historical Armenia. The observed patterns highlight a remarkable degree of matrilineal genetic heterogeneity and weak population structuring of Armenians. Moreover, our phylogeographic analysis reveals common ancestries for some mtDNA lineages shared by West Asians, Transcaucasians, Europeans, Central Asians and Armenians. About third of the mtDNA subhaplogroups found in Armenian gene pool might be considered as Armenian-specific, as these are virtually absent elsewhere in Europe, West Asia and Transcaucasia. Coalescence ages of most of these lineages do not exceed 3.1 kya and coincide well with the population size growth started around 1.8-2.8 kya detectable only in the Bayesian Skyline Plots based on the Armenian-specific mtDNA haplotypes.

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Citations

Apr 11, 2020·American Journal of Physical Anthropology·Alla A MovsesianHasmik G Simonyan
Nov 11, 2021·Molecular Genetics and Genomics : MGG·Miroslava DerenkoBoris Bazarov

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Methods Mentioned

BETA
MDS
dissection

Software Mentioned

DnaSP
BEAST
STATISTICA
Arlequin
SeqScape
PhyloTree Build
mtPhyl
PhyloTree

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