Insights into Mechanisms of Chronic Neurodegeneration

International Journal of Molecular Sciences
Abigail B DiackJean C Manson

Abstract

Chronic neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and prion diseases are characterised by the accumulation of abnormal conformers of a host encoded protein in the central nervous system. The process leading to neurodegeneration is still poorly defined and thus development of early intervention strategies is challenging. Unique amongst these diseases are Transmissible Spongiform Encephalopathies (TSEs) or prion diseases, which have the ability to transmit between individuals. The infectious nature of these diseases has permitted in vivo and in vitro modelling of the time course of the disease process in a highly reproducible manner, thus early events can be defined. Recent evidence has demonstrated that the cell-to-cell spread of protein aggregates by a "prion-like mechanism" is common among the protein misfolding diseases. Thus, the TSE models may provide insights into disease mechanisms and testable hypotheses for disease intervention, applicable to a number of these chronic neurodegenerative diseases.

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Citations

Jun 29, 2017·Prion·Jay RasmussenLary C Walker
Feb 16, 2018·Neurology·Eduardo E Benarroch
Sep 28, 2018·Nature Neuroscience·Mathias Jucker, Lary C Walker
Nov 28, 2016·Molecular Neurobiology·Marta SochockaJerzy Leszek
Jul 6, 2019·Frontiers in Neuroscience·Jiangnan MaAnmu Xie
Aug 24, 2018·Translational Psychiatry·A Relaño-GinésC Crozet
Dec 4, 2019·Ecology and Evolution·Emma K Trone-LaunerChristopher N Jacques

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Methods Mentioned

BETA
transgenic
glycosylation
gene
targeted knock-in

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