Insights into morphological nature of precipitation of cholesterol

Steroids
Vuk Uskoković

Abstract

Additional effects on the previously reported procedure of precipitation of narrowly dispersed and well-defined, brick-shaped cholesterol particles, including non-solvent addition rate, temperature, solvent purity, aging treatments, ultrasound agitation and fine mechanical effects were investigated. Based on the presented results, significant morphological sensitivity of cholesterol precipitation processes upon variations from the standard established procedure of crystallization is induced. However, the tendency of cholesterol to crystallize in the form of biaxially grown particles was evidenced as dominating the precipitation processes, irrespective of any modifications of experimental parameters involved in the preparation procedure investigated hereby. Prolonged aging time and temperature effects lead to "face-to-face" aggregation of particles, promoted by the discrepancy in surface charges between particle sides and faces. In light of these observations, the mechanism of precipitation of cholesterol is further discussed.

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Citations

Jul 25, 2009·The Journal of Chemical Physics·S R T Cromie, P Ballone
Jan 1, 2009·Technoetic Arts : a Journal of Speculative Research·Vuk Uskoković
Aug 2, 2013·Journal of Dispersion Science and Technology·Vuk Uskoković
Nov 10, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vuk Uskoković, Dragan P Uskoković
Jun 8, 2018·Chemistry : a European Journal·Marieh B Al-HandawiPanče Naumov
Apr 29, 2010·Natural Product Reports·James R Hanson
Feb 27, 2020·Drug Delivery and Translational Research·Ali FarmoudehAli Nokhodchi
Dec 16, 2017·Food & Function·Krassimir P VelikovSergey M Melnikov
Nov 1, 2010·Journal of Biomimetics, Biomaterials, and Tissue Engineering·Vuk Uskoković
Oct 22, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Santanu Bhattacharya, Joydeep Biswas

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