Insights into PBDE Uptake, Body Burden, and Elimination Gained from Australian Age-Concentration Trends Observed Shortly after Peak Exposure

Environmental Health Perspectives
Tenzing GyalpoKonrad Hungerbühler

Abstract

Population pharmacokinetic models combined with multiple sets of age-concentration biomonitoring data facilitate back-calculation of chemical uptake rates from biomonitoring data. We back-calculated uptake rates of PBDEs for the Australian population from multiple biomonitoring surveys (top-down) and compared them with uptake rates calculated from dietary intake estimates of PBDEs and PBDE concentrations in dust (bottom-up). Using three sets of PBDE elimination half-lives, we applied a population pharmacokinetic model to the PBDE biomonitoring data measured between 2002-2003 and 2010-2011 to derive the top-down uptake rates of four key PBDE congeners and six age groups. For the bottom-up approach, we used PBDE concentrations measured around 2005. Top-down uptake rates of Σ4BDE (the sum of BDEs 47, 99, 100, and 153) varied from 7.9 to 19 ng/kg/day for toddlers and from 1.2 to 3.0 ng/kg/day for adults; in most cases, they were--for all age groups--higher than the bottom-up uptake rates. The discrepancy was largest for toddlers with factors up to 7-15 depending on the congener. Despite different elimination half-lives of the four congeners, the age-concentration trends showed no increase in concentration with age and were similar ...Continue Reading

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Citations

Dec 30, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Leisa-Maree Leontjew TomsFiona A Harden
Apr 6, 2018·Journal of Exposure Science & Environmental Epidemiology·Whitney J CowellJulie B Herbstman
Dec 17, 2015·Environmental Health Perspectives·Tenzing GyalpoKonrad Hungerbühler
Nov 13, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Nikos StratakisVaia Lida Chatzi

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