Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies

Journal of Immunological Methods
Warren LeeChiuan Herng Leow

Abstract

The advantages of chicken (Gallus gallus domesticus) antibodies as immunodiagnostic and immunotherapeutic biomolecules has only been recently recognized. Even so, chicken antibodies remain less-well characterized than their mammalian counterparts. This review aims at providing a current overview of the structure, function, development and generation of chicken antibodies. Additionally, brief but comprehensive insights into current knowledge pertaining to the immunogenetic framework and diversity-generation of the chicken immunoglobulin repertoire which have contributed to the establishment of recombinant chicken mAb-generating methods are discussed. Focus is provided on the current methods used to generate antibodies from chickens with added emphasis on the generation of recombinant chicken mAbs and its derivative formats. The advantages and limitations of established protocols for the generation of chicken mAbs are highlighted. The various applications of recombinant chicken mAbs and its derivative formats in immunodiagnostics and immunotherapy are further detailed.

Citations

Sep 20, 2018·Human Vaccines & Immunotherapeutics·Aymn Talat AbbasEsam Ibraheem Ahmed Azhar
Jun 17, 2020·Experimental and Therapeutic Medicine·Carolina ConstantinDemetrios A Spandidos
Jun 25, 2019·The Journal of Clinical Investigation·Laura KähäriMarko Salmi
May 15, 2021·Veterinary Research·Shikun GeXiaoying Zhang
Oct 6, 2021·Critical Reviews in Food Science and Nutrition·Md Rashedul IslamHany Anany
Jan 7, 2022·Journal of Agricultural and Food Chemistry·Leina DouZhanhui Wang

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