Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging.

Biomolecules
Rashmi DahiyaMd Imtaiyaz Hassan

Abstract

Aging represents a significant biological process having strong associations with cancer, diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive loss of cellular functions and viability. Astonishingly, age-related disorders share several genetic and molecular mechanisms with the normal aging process. Over the last three decades, budding yeast Saccharomyces cerevisiae has emerged as a powerful yet simple model organism for aging research. Genetic approaches using yeast RLS have led to the identification of hundreds of genes impacting lifespan in higher eukaryotes. Numerous interventions to extend yeast lifespan showed an analogous outcome in multi-cellular eukaryotes like fruit flies, nematodes, rodents, and humans. We collected and analyzed a multitude of observations from published literature and provide the contribution of yeast in the understanding of aging hallmarks most applicable to humans. Here, we discuss key pathways and molecular mechanisms that underpin the evolutionarily conserved aging process and summarize the current understanding and clinical applicability of its trajectories. Gathering critical information on aging biology would pave the way for future investigation targeted at...Continue Reading

References

Nov 1, 1991·Journal of Bacteriology·N P D'Mello, S M Jazwinski
Apr 1, 1987·Experimental Cell Research·Y IshimiF Hanaoka
Aug 21, 1972·Biochemical and Biophysical Research Communications·J M Ryan, V J Cristofalo
Jun 3, 1983·Science·V L Wilson, P A Jones
Feb 15, 1996·Biochemical and Biophysical Research Communications·S KimS M Jazwinski
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·N R Austriaco, L P Guarente
Jan 15, 1998·Cell·D A Sinclair, L Guarente
Nov 23, 2000·Nature·L Guarente, C Kenyon
May 25, 2002·Molecular and Cellular Biology·Laura L Mays HoopesJudith L Campbell
Jul 2, 2002·Lancet·Tom VulliamyPhilip J Mason
Jul 27, 2002·Science·Richard D KolodnerKyungjae Myung
Aug 3, 2002·The Journal of Biological Chemistry·Bettina SargHerbert H Lindner
Sep 6, 2002·Annual Review of Microbiology·S Michal Jazwinski
Oct 10, 2002·Current Biology : CB·James LundThomas E Johnson
Jun 20, 1959·Nature·R K MORTIMER, J R JOHNSTON
Nov 13, 2003·Molecular and Cellular Biology·Jennifer A Hackett, Carol W Greider
Jan 14, 2004·Molecular Biology of the Cell·Isabelle Lesur, Judith L Campbell
Jan 16, 2004·Genes & Development·Su-Ju LinLeonard Guarente
Jun 10, 2004·Current Biology : CB·Pankaj KapahiSeymour Benzer
Aug 26, 2004·PLoS Biology·Matt KaeberleinBrian K Kennedy
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Blanka Rogina, Stephen L Helfand
Nov 5, 2004·Nature·Yentram HuyenThanos D Halazonetis
Nov 9, 2004·Nature Structural & Molecular Biology·Timothy S FisherVirginia A Zakian
Jan 22, 2005·The Journal of Biological Chemistry·Wei-Jong ShiaJerry L Workman
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Nov 29, 2005·PLoS Genetics·Matt KaeberleinBrian K Kennedy

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Citations

Dec 4, 2020·Cellular Signalling·Ruijuan XuCungui Mao
Feb 23, 2021·Life Sciences in Space Research·Ana Paula Montanari FukudaJose Ribamar Ferreira-Junior
Jul 7, 2021·Cell Death Discovery·Maryam MazharSijin Yang
Nov 30, 2021·Journal of Cardiovascular Pharmacology·Musammat Kulsuma BegumYu Wang

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Methods Mentioned

BETA
acetylation
Histone acetylation
GTPase
protein folding

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