Insights into the evolution of metazoan regenerative mechanisms: roles of TGF superfamily members in tissue regeneration of the marine sponge Chondrosia reniformis

The Journal of Experimental Biology
Marina PozzoliniSonia Scarfì

Abstract

Tissue repair is an adaptive and widespread metazoan response. It is characterised by different cellular mechanisms and complex signalling networks that involve numerous growth factors and cytokines. In higher animals, transforming growth factor-β (TGF-β) signalling plays a fundamental role in wound healing. In order to evaluate the involvement of TGF superfamily members in lower invertebrate tissue regeneration, sequences for putative TGF ligands and receptors were isolated from the transcriptome of the marine sponge Chondrosia reniformis We identified seven transcripts that coded for TGF superfamily ligands and three for TGF superfamily receptors. Phylogenetically, C. reniformis TGF ligands were not grouped into any TGF superfamily clades and thus presumably evolved independently, whereas the TGF receptors clustered in the Type I receptor group. We performed gene expression profiling of these transcripts in sponge regenerating tissue explants. Data showed that three ligands (TGF1, TGF3 and TGF6) were mainly expressed during early regeneration and seemed to be involved in stem cell maintenance, whereas two others (TGF4 and TGF5) were strongly upregulated during late regeneration and thus were considered pro-differentiating fac...Continue Reading

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Citations

May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio LuparelloMirella Vazzana
Nov 15, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Alexander V EreskovskyAndrey I Lavrov
Aug 23, 2020·Cells·Letizia ZulloSimona Candiani
Jul 6, 2021·Frontiers in Immunology·Lara SchmittmannLucía Pita

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