Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians

Annals of the New York Academy of Sciences
Stephanie Y L NgBilly K C Chow

Abstract

Glucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon genes or exons that are likely resultant of duplication events. Through phylogenetic analysis and examination of their respective functions, the proglucagon ligand-receptor pairs are believed to have evolved independently before acquiring specificity for one another. This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species.

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Citations

Aug 17, 2011·Diabetes, Obesity & Metabolism·D M Irwin, K J Prentice
May 29, 2014·Journal of Molecular Endocrinology·Janice K V TamBilly K C Chow
Mar 22, 2014·General and Comparative Endocrinology·David M Irwin
May 7, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Kazuhisa Honda
Mar 7, 2018·General and Comparative Endocrinology·David M Irwin, Svetlana Mojsov
Jul 6, 2021·Frontiers in Endocrinology·Peter LindquistAlexander S Hauser

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