Insights Into the Function of the NuA4 Complex in Plants

Frontiers in Plant Science
Loreto Espinosa-CoresManuel Piñeiro

Abstract

Chromatin remodeling plays a key role in the establishment and maintenance of gene expression patterns essential for plant development and responses to environmental factors. Post-translational modification of histones, including acetylation, is one of the most relevant chromatin remodeling mechanisms that operate in eukaryotic cells. Histone acetylation is an evolutionarily conserved chromatin signature commonly associated with transcriptional activation. Histone acetylation levels are tightly regulated through the antagonistic activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs). In plants, different families of HATs are present, including the MYST family, which comprises homologs of the catalytic subunit of the Nucleosome Acetyltransferase of H4 (NuA4) complex in yeast. This complex mediates acetylation of histones H4, H2A, and H2A.Z, and is involved in transcriptional regulation, heterochromatin silencing, cell cycle progression, and DNA repair in yeast. In Arabidopsis and, other plant species, homologs for most of the yeast NuA4 subunits are present and although the existence of this complex has not been demonstrated yet, compelling evidence supports the notion that this type of HAT complex functi...Continue Reading

References

Mar 19, 1999·Molecular and Cellular Biology·A S ClarkeL Pillus
Jan 19, 2000·Nature·B D Strahl, C D Allis
Jun 5, 2002·Annual Review of Biochemistry·Ivan A OlaveGerald R Crabtree
Sep 28, 2002·Nature·Alexander W BirdMichael F Christman
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Muthugapatti K KandasamyRichard B Meagher
Jun 5, 2003·Genes & Development·Alexandre A BoudreaultJacques Côté
Jan 1, 2004·Molecular and Cellular Biology·Juliet L ReidKevin Struhl
Feb 18, 2004·Molecular and Cellular Biology·Yannick DoyonJacques Côté
Jun 16, 2004·Current Opinion in Genetics & Development·Yannick Doyon, Jacques Côté
Aug 11, 2004·Eukaryotic Cell·Claudia B BittnerRobert K Slany
Sep 10, 2004·Molecular Biology and Evolution·Gordon H Y HeKarl Riabowol
Aug 27, 2005·Cell·Dmitry K PokholokRichard A Young
Dec 13, 2005·Plant Physiology·Richard B MeagherElizabeth C McKinney
Mar 18, 2006·Genes & Development·Michael-Christopher KeoghStephen Buratowski
Mar 18, 2006·Genes & Development·Catherine B MillarMichael Grunstein
May 16, 2006·The International Journal of Biochemistry & Cell Biology·Vasileia SapountziCraig N Robson
May 27, 2006·Nature·Pedro V PeñaTatiana G Kutateladze
Feb 27, 2007·Cell·Tony Kouzarides
Mar 17, 2007·Annual Review of Biochemistry·Mona D Shahbazian, Michael Grunstein
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Kenneth K Lee, Jerry L Workman
Sep 20, 2007·The Plant Journal : for Cell and Molecular Biology·Keith W EarleyCraig S Pikaard
Nov 7, 2007·Nature Structural & Molecular Biology·Sukesh R BhaumikAli Shilatifard
Apr 15, 2008·Nature Structural & Molecular Biology·Heather SzerlongBradley R Cairns
Dec 2, 2008·BMC Plant Biology·David LatrasseMarianne Delarue
Jan 22, 2009·The Plant Journal : for Cell and Molecular Biology·Woo Yong LeeChang Seob Kwon
Sep 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne K Voss, Tim Thomas
Oct 14, 2009·Molecular and Cellular Biology·Daniel S GinsburgAlan G Hinnebusch
Nov 10, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Phoebe Y T LuMichael S Kobor

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Citations

May 1, 2021·Biology·Malgorzata KlocRafik M Ghobrial

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Methods Mentioned

BETA
histone acetylation
electron microscopy
acetylation
affinity purification
co-immunoprecipitation
pulldown
Co-IP
immunoprecipitation
transgenic
RNA-seq

Software Mentioned

SMART
HMMER

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