Insights into the genetic architecture of diabetic nephropathy.

Current Diabetes Reports
Nicholette D Palmer, Barry I Freedman

Abstract

Diabetic nephropathy (DN) is a devastating complication of type 1 and type 2 diabetes and leads to increased morbidity and premature mortality. Susceptibility to DN has an inherent genetic basis as evidenced by familial aggregation and ethnic-specific prevalence rates. Progress in identifying the underlying genetic architecture has been arduous with the realization that a single locus of large effect does not exist, unlike in predisposition to non-diabetic nephropathy in individuals with African ancestry. Numerous risk variants have been identified, each with a nominal effect, and they collectively contribute to disease. These results have identified loci targeting novel pathways for disease susceptibility. With continued technological advances and development of new analytic methods, additional genetic variants and mechanisms (e.g., epigenetic variation) will be identified and help to elucidate the pathogenesis of DN. These advances will lead to early detection and development of novel therapeutic strategies to decrease the incidence of disease.

References

May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanB J Spray
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanV M Buckalew
Sep 13, 1996·Science·N Risch, K Merikangas
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D F O'DeaP S Parfrey
Jun 16, 1999·Diabetes Research and Clinical Practice·V VijayA Ramachandran
Mar 30, 2000·Annals of Human Genetics·L H WiseC M Lewis
Mar 29, 2002·American Journal of Nephrology·James GitterBarry I Freedman
May 4, 2002·Nature Reviews. Genetics·Holly K TaborRichard M Myers
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Sylvia Paz B RamirezStephen I-Hong Hsu
Oct 5, 2002·Hypertension·Eisei NoiriToshiro Fujita
Nov 13, 2002·Kidney International·Irfan VardarliBart Janssen
Jun 6, 2003·The New England Journal of Medicine·Bruce A PerkinsAndrzej S Krolewski
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
May 22, 2004·Nature Reviews. Genetics·UNKNOWN International HapMap Consortium
Dec 14, 2004·Genetic Epidemiology·Elias Zintzaras, John P A Ioannidis
Jan 12, 2005·Journal of Diabetes and Its Complications·William C KnowlerUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Mar 4, 2005·Journal of the American Society of Nephrology : JASN·Yongmei LiuBarry I Freedman
Jun 16, 2005·Bioinformatics·Elias Zintzaras, John P A Ioannidis
Sep 24, 2005·American Journal of Nephrology·Barry I FreedmanWilliam M McClellan
Sep 29, 2005·Molecular Psychiatry·T A TrikalinosJ P A Ioannidis
Jul 27, 2006·Human Genetics·Elias ZintzarasJohn P A Ioannidis
Jan 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry I FreedmanDonald W Bowden
Mar 17, 2007·Diabetes·Sudha K IyengarUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Nov 16, 2007·Diabetes·Jeffrey R SchellingUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
May 3, 2008·The Journal of Clinical Investigation·Teri A ManolioFrancis S Collins
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zongzhong TongKang Zhang
Sep 17, 2008·Nature Genetics·W H Linda KaoUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Sep 17, 2008·Nature Genetics·Jeffrey B KoppCheryl A Winkler
Dec 17, 2008·American Journal of Human Genetics·Bing HeKarl Tryggvason
Apr 24, 2009·Kidney International·Cristian PattaroUNKNOWN EUROSPAN Consortium

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Citations

Sep 24, 2013·Molecular Biology Reports·Farook ThameemHanna E Abboud
Dec 25, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dorothee AtzlerTanja Zeller
Aug 14, 2013·Annals of Human Genetics·Habiba S Al SafarJenefer M Blackwell
May 21, 2014·Journal of Diabetes Investigation·Norihiro Kato
Aug 25, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Katherine CarranzaDelma Veron
Jul 28, 2016·Diabetes/metabolism Research and Reviews·Nektaria Papadopoulou-MarketouChristina Kanaka-Gantenbein
Jul 18, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Shadia A FathyAbdulnabi T Alattar
Jan 30, 2019·Genetic Testing and Molecular Biomarkers·Maria TziastoudiElias Zintzaras
Jun 21, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Jason A BonomoDonald W Bowden
Nov 18, 2016·American Journal of Physiology. Renal Physiology·Mette V ØstergaardRichard J M Coward
Feb 3, 2016·Clinical Science·Melinda T CoughlanJosephine M Forbes
Dec 20, 2020·The FEBS Journal·Rohan Goyal, Pravin C Singhal

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