Insights into the mechanisms of alveolarization - Implications for lung regeneration and cell therapies.

Seminars in Fetal & Neonatal Medicine
Maria HurskainenBernard Thébaud

Abstract

Although the lung has extensive regenerative capacity, some diseases affecting the distal lung result in irreversible loss of pulmonary alveoli. Hitherto, treatments are supportive and do not specifically target tissue repair. Regenerative medicine offers prospects to promote lung repair and regeneration. The neonatal lung may be particularly receptive, because of its growth potential, compared to the adult lung. Based on our current understanding of neonatal lung injury, the ideal therapeutic approach includes mitigation of inflammation and fibrosis, and induction of regenerative signals. Cell-based therapies have shown potential to prevent and reverse impaired lung development. Their mechanisms of action suggest effects on both, mitigating the pathophysiological processes and promoting lung growth. Here, we review our current understanding of normal and impaired alveolarization, provide some rationale for the use of cell-based therapies and summarize current evidence for the therapeutic potential of cell-based therapies for pulmonary regeneration in preterm infants.

References

Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Bernard Thébaud, Steven H Abman
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Muhammad AslamStella Kourembanas
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Timothy van HaaftenBernard Thébaud
Oct 15, 2010·Journal of Cellular Physiology·Branka DabovicDaniel B Rifkin
Jan 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mandy LauA Keith Tanswell
Jun 7, 2011·American Journal of Obstetrics and Gynecology·Patricia VosdoganesTimothy J M Moss
Mar 8, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Allison N LauDaniel J Weiss
Oct 10, 2012·Cell Transplantation·Patricia VosdoganesRebecca Lim
Dec 3, 2013·Nature Biotechnology·Sarah X L HuangHans-Willem Snoeck
Feb 11, 2014·The Journal of Pediatrics·Yun Sil ChangWon Soon Park
Mar 29, 2014·American Journal of Respiratory Cell and Molecular Biology·Yun Sil ChangWon Soon Park
Apr 14, 2015·Nature Communications·Rajan JainJonathan A Epstein
Jul 21, 2015·American Journal of Respiratory Cell and Molecular Biology·Laurie C EldredgeJohn K McGuire
Nov 21, 2015·Development·Jun YangJichao Chen
Jul 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Po-Nien TsaoMitsuru Morimoto
Dec 15, 2016·American Journal of Respiratory Cell and Molecular Biology·Min YeeMichael A O'Reilly
Feb 2, 2017·Cell and Tissue Research·Johannes C Schittny
Feb 24, 2017·Cell Reports·Simona SaluzzoSylvia Knapp
Apr 25, 2017·Nature Cell Biology·Ya-Wen ChenHans-Willem Snoeck
Aug 31, 2017·American Journal of Respiratory and Critical Care Medicine·Gareth R WillisStella Kourembanas
Nov 9, 2017·Molecular and Cellular Pediatrics·Prajakta Oak, Anne Hilgendorff
Jan 27, 2018·Cellular Immunology·Nikita JoshiAlexander V Misharin
Feb 9, 2018·Science·Ahmad N NabhanTushar J Desai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Respiratory Research
José Alberto Rodríguez-CastilloKatrin Ahlbrecht
Expert Opinion on Biological Therapy
Jonathan L McQualter
Translational Research : the Journal of Laboratory and Clinical Medicine
Kristen ThaneAndrew M Hoffman
© 2021 Meta ULC. All rights reserved