PMID: 9434898Jan 22, 1998Paper

Insights into the mechanisms of homologous recombination from the structure of RuvA

Current Opinion in Structural Biology
D W RiceR G Lloyd

Abstract

The recent structure determination of RuvA has provided the first insights into the structural basis for its interaction with Holliday junction DNA. Multiple copies of a helix-hairpin-helix motif which line the four grooves between the monomers in the tetrameric structure are thought to be involved in the interaction of the protein with its DNA target. This suggests that the four arms of the junction are held by RuvA in a fourfold symmetric arrangement and has fuelled ideas on the way in which components of the Ruv complex combine to catalyse the process of homologous recombination.

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Citations

Jun 17, 1998·Nature Structural Biology·D HargreavesJ B Rafferty
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·M AriyoshiK Morikawa
Oct 17, 1998·Molecular Cell·S M RoeL H Pearl
Nov 14, 1998·Cell·M SeigneurB Michel
Feb 3, 2016·Molecular & Cellular Proteomics : MCP·Mahadevan LakshminarasimhanMichael P Washburn
Nov 24, 2004·The Journal of Biological Chemistry·Cyril V PrivezentzevIrina R Tsaneva
Dec 7, 2002·Journal of Theoretical Biology·Michael F Bruist, Eric Myers

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