Insights into the molecular pathogenesis of ocular tuberculosis.

Tuberculosis
Rupesh AgrawalCarlos Pavesio

Abstract

Unclear pathogenic mechanisms underlying the ocular tuberculosis (OTB) has resulted in perplexity related to the diagnosis and management of the disease. Developments in experimental research and innovations in molecular diagnostics have recently provided a new understanding of disease pathogenesis and natural history. The current review focuses on the new insights into OTB pathogenesis, derived from in vivo and in vitro studies on Mycobacterium tuberculosis dissemination and localization into the eye, in combination with histopathological studies on chorioretinal tissue and vascular network. Advances in the knowledge of OTB have influenced disease management in the clinical setting and lead to reconsideration of the role of existing treatments and suggesting potential new therapeutic approaches.

References

Dec 13, 2006·Archives of Ophthalmology·Narsing A RaoRonald E Smith
Nov 22, 2007·Survey of Ophthalmology·Vishali GuptaNarsing A Rao
Apr 1, 1949·The British Journal of Ophthalmology·A C WOODS
Apr 7, 2009·Ophthalmology·Simon R J TaylorSue L Lightman
Sep 16, 2009·Archives of Ophthalmology·Narsing A RaoPetros C Karakousis
Apr 9, 2010·International Ophthalmology Clinics·Ahmed M Abu El-AsrarHani S Al-Mezaine
Nov 9, 2010·Ophthalmology·Keith J WroblewskiMichael Zapor
Apr 5, 2012·Ophthalmology·Simon R J TaylorSue Lightman
Mar 20, 2014·The British Journal of Ophthalmology·James T Rosenbaum
Apr 12, 2014·JAMA Ophthalmology·Hossein NazariNarsing A Rao
Oct 15, 2014·Ocular Immunology and Inflammation·Amod GuptaKusum Sharma
Nov 5, 2014·European Journal of Ophthalmology·Alessandro InvernizziGiovanni Staurenghi
Jan 24, 2015·Ocular Immunology and Inflammation·Rupesh AgrawalCarlos E Pavesio
Mar 31, 2015·The Journal of Clinical Investigation·Toidi AdekambiJyothi Rengarajan
Jan 10, 2016·Investigative Ophthalmology & Visual Science·Kathryn L PeppleRussell N Van Gelder
Mar 13, 2016·Survey of Ophthalmology·Ae Ra KeeRupesh Agrawal
Jul 29, 2016·Ocular Immunology and Inflammation·Ravi K SharmaNaresh Sachdeva
Oct 28, 2016·Nature Reviews. Disease Primers·Madhukar PaiMario Raviglione
Nov 7, 2016·The British Journal of Ophthalmology·Marcus Ang, Soon-Phaik Chee
Oct 28, 2017·JAMA Ophthalmology·Rupesh AgrawalUNKNOWN Collaborative Ocular Tuberculosis Study (COTS)–1 Study Group
Nov 5, 2017·Investigative Ophthalmology & Visual Science·Ravichandra TagirasaSoumyava Basu
Nov 29, 2017·Microbial Pathogenesis·Soumyava BasuNarsing A Rao
Dec 1, 2017·Ocular Immunology and Inflammation·Aniruddha AgarwalVishali Gupta
Aug 1, 2015·Ocular Immunology and Inflammation·Soumyava BasuNarsing A Rao
Jan 31, 2018·International Ophthalmology·Murat HasanreisogluSengul Ozdek
Mar 28, 2018·PloS One·Kevin TakakiSoumyava Basu
Apr 7, 2018·Investigative Ophthalmology & Visual Science·Rina La Distia NoraMariëlle C Haks
May 8, 2018·Immunological Investigations·Ravi Kumar SharmaNaresh Sachdeva
Aug 19, 2018·Investigative Ophthalmology & Visual Science·Rupesh AgrawalUNKNOWN Collaborative Ocular Tuberculosis Study Group
Apr 16, 2019·Ocular Immunology and Inflammation·Sahil JainVishali Gupta
Apr 17, 2019·PLoS Medicine·Adam Penn-NicholsonUNKNOWN ACS and GC6–74 cohort study groups
Mar 13, 2020·Frontiers in Cellular and Infection Microbiology·Madeleine G Moule, Jeffrey D Cirillo
Apr 2, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qianting YangLi Ma
May 15, 2020·Ocular Immunology and Inflammation·Soumyava BasuPaul Elkington

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Citations

Nov 21, 2021·The British Journal of Ophthalmology·Maite Sainz de La MazaVíctor Llorenç

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