Insights into the potential use of microRNAs as a novel class of biomarkers in esophageal cancer

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
J WanR Zhang

Abstract

MicroRNAs (abbreviated miRNAs) have been demonstrated to be involved in tumorigenesis and cancer development and proposed as promising biomarkers in cancer diagnosis. Numerous studies have observed the aberrant expression of miRNAs in esophageal cancer. However, there are some discrepant results. Thus, we conducted this meta-analysis to identify the overall accuracy of miRNAs in the diagnosis of esophageal cancer. A comprehensive literature search was conducted in PubMed and other databases using combinations of key words. The summary receiver operator characteristic curves were plotted to assess the overall diagnostic performance of miRNAs. Chi-squared and I(2) tests were used to assess the heterogeneity between studies. Additionally, we conducted subgroup and sensitivity analyses to analyze the potential sources of heterogeneity. In total, 33 studies from 12 articles were available in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR) diagnostic odds ratio, and area under the curve were 0.80, 0.80, 4.0, 0.25, 16, and 0.87, respectively. Subgroup analyses based on the sample types (saliva-, serum- and plasma-based) showed no differences in the diagnostic accuracy of each ...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M C HollsteinC C Harris
Jan 1, 1995·British Journal of Cancer·J AdélaideD Birnbaum
May 9, 2000·Journal of the American College of Surgeons·J M DalyA M Fremgen
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jul 20, 2004·BMJ : British Medical Journal·Jonathan J Deeks, Douglas G Altman
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Aug 4, 2007·International Journal of Cancer. Journal International Du Cancer·Toru HiyamaKazuaki Chayama
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Andrew FeberVirginia R Litle
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Yuji TachimoriHoichi Kato
Oct 17, 2009·Gut·T ParanjapeJ B Weidhaas
Jan 16, 2010·The Journal of Biological Chemistry·Yanyan TianZhihua Liu
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
Jul 1, 2010·Digestion·Kayoko MatsushimaKazuhiko Nakao
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Nov 26, 2010·Molecular Biology Reports·Wen-Jing MaXiao-Mei Lu
Jan 25, 2011·Journal of Surgical Oncology·Tad KimSteven N Hochwald
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jun 16, 2011·British Journal of Cancer·S KomatsuE Otsuji
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Mar 8, 2012·Journal of the National Cancer Institute·Viswam S NairJohn P A Ioannidis
May 29, 2012·Journal of Cancer Research and Clinical Oncology·Bing Wang, Qingyun Zhang
Jul 4, 2012·Molecular Medicine Reports·Bin HeJingqun Tang
Aug 16, 2012·Journal of Toxicology and Environmental Health. Part a·Ran LiuLihong Yin
Feb 5, 2013·Advances in Experimental Medicine and Biology·Thalia A FaraziThomas Tuschl
Jun 27, 2013·Frontiers in Genetics·Dharanija MadhavanRongxi Yang
Jan 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hui LiAnjia Han
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gabriella SozziUgo Pastorino
Nov 5, 2014·Medical Oncology·Mohammad Amin JavidiMajid Sadeghizadeh

❮ Previous
Next ❯

Citations

Jun 27, 2015·Thrombosis Research·Cinzia CiccacciPaola Borgiani
Sep 2, 2017·The International Journal of Biological Markers·Mei LiFeng Li
Nov 5, 2017·Scientific Reports·Laiyi Fu, Qinke Peng
May 1, 2020·World Journal of Gastroenterology : WJG·Ling-Yu ChuYi-Wei Xu
May 22, 2021·Journal of Clinical Laboratory Analysis·Xi LiuKang Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yanying WangYong Gao
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Lijun ShenShaojie Xin
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Lihua LiuJianchao Liu
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Changlong HouShiting Feng
© 2021 Meta ULC. All rights reserved