Insights into the role of connexins in mammary gland morphogenesis and function

Reproduction : the Official Journal of the Society for the Study of Fertility
Michael K G StewartDale W Laird

Abstract

Gap junctions formed of connexin subunits link adjacent cells by direct intercellular communication that is essential for normal tissue homeostasis in the mammary gland. The mammary gland undergoes immense remodeling and requires exquisite regulation to control the proliferative, differentiating, and cell death mechanisms regulating gland development and function. The generation of novel genetically modified mice with reduced or ablated connexin function within the mammary gland has advanced our understanding of the role of gap junctions during the complex and dynamic process of mammary gland development. These studies have revealed an important stage-specific role for Cx26 (GJA1) and Cx43 (GJB2), while Cx30 (GJB6) and Cx32 (Gjb1) can be eliminated without compromising the gland. Yet, there remain gaps in our understanding of the role of mammary gland gap junctions.

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Citations

Jun 17, 2016·Molecular & Cellular Oncology·Qian Shi, Jean X Jiang
Nov 20, 2015·Cancer Letters·Jimmy S PatelPranela Rameshwar
Jul 8, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Gerald M Kidder, Elke Winterhager
Apr 30, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Loic HamonDavid Pastré
Jul 30, 2016·Frontiers in Physiology·Aridany Suárez-Trujillo, Theresa M Casey
Jun 29, 2017·Biochimica Et Biophysica Acta. Biomembranes·Marc MesnilChristian C Naus
Mar 3, 2018·International Journal of Molecular Sciences·Mélanie BusbyIsabelle Plante
Mar 27, 2020·Trends in Cancer·Garima SinhaPranela Rameshwar

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