Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders.

Frontiers in Aging Neuroscience
Banglian HuHonghua Zheng


The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular protein fragment, supports the survival of myeloid cells upon activation by two ligands, colony stimulating factor 1 and interleukin 34. CSF1R loss-of-function mutations are the major cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its dysfunction has also been implicated in other neurodegenerative disorders including Alzheimer's disease (AD). Here, we review the physiological functions of CSF1R in the CNS and its pathological effects in neurological disorders including ALSP, AD, frontotemporal dementia and multiple sclerosis. Understanding the pathophysiology of CSF1R is critical for developing targeted therapies for related neurological diseases.


Apr 10, 1992·Science·J A Hardy, G A Higgins
Nov 1, 1996·Journal of Leukocyte Biology·P Dello SbarbaM G Cipolleschi
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E RovidaP Dello Sbarba
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Mark E Fortini
Jun 28, 2005·Developmental and Comparative Immunology·Daniel R BarredaMiodrag Belosevic
Jun 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yun-wu ZhangHuaxi Xu
Nov 30, 2007·Current Molecular Medicine·Yun-wu Zhang, Huaxi Xu
Jan 10, 2008·Trends in Immunology·Gillian MurphyRama Khokha
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Xuemin Xu
Jun 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shunichi KosugiHiroshi Yanagawa
Jun 19, 2009·Nature Immunology·Daniel W McVicar, Giorgio Trinchieri
May 1, 2010·Journal of Leukocyte Biology·Nathalie Droin, Eric Solary
Jan 11, 2011·Molecular Brain·Yun-wu ZhangHuaxi Xu
Nov 30, 2011·Journal of Neurochemistry·Han ZhangHuaxi Xu
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Jul 21, 2012·Nature Immunology·Teresa Zelante, Paola Ricciardi-Castagnoli
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Jan 9, 2013·The Journal of Experimental Medicine·Jian LuoTony Wyss-Coray
Feb 15, 2013·Neurology·Alexandra M NicholsonRosa Rademakers
Jun 22, 2013·Parkinsonism & Related Disorders·Christina SundalZbigniew K Wszolek
Jul 31, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A D SadovnickC Vilariño-Güell
Feb 25, 2014·Neuron·Takahisa KanekiyoGuojun Bu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.