Insights into the role of IL-32 in cancer

Seminars in Immunology
Yvette J E SlootRomana T Netea-Maier

Abstract

Interleukin 32 (IL-32) is a proinflammatory cytokine involved in the development of several diseases, including cancer. IL-32 is a rather peculiar cytokine because its protein structure does not show resemblance with any of the known cytokines, and an IL-32 receptor to facilitate extracellular signaling has not yet been identified. Thus far, 9 isoforms of IL-32 have been described, all of which show differences in terms of effects and in potency to elicit a specific effect. Since the first report of IL-32 in 2005, there is increasing evidence that IL-32 plays an important role in the pathophysiology of both hematologic malignancies and solid tumors. Some IL-32 isoforms have been linked to disease outcome and were shown to positively influence tumor development and progression in various different malignancies, including gastric, breast and lung cancers. However, there are other reports suggesting a tumor suppressive role for some of IL-32 as well. For example, IL-32γ and IL-32β expression is associated with increased cancer cell death in colon cancer and melanoma, whereas expression of these isoforms is associated with increased invasion and migration in breast cancer cells. Furthermore, IL-32 isoforms α, β and γ also play an i...Continue Reading

Citations

Dec 7, 2018·International Journal of Molecular Sciences·Joseph Antoine Salvator FabreArmand Bensussan
Jun 4, 2020·Arthritis Research & Therapy·Paola Di BenedettoRoberto Giacomelli
Oct 18, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jovani Catalan-DibeneAlbert Zlotnik
Sep 2, 2020·Journal of Leukocyte Biology·Kristin Roseth AassTherese Standal
Aug 26, 2020·JCI Insight·Thomas GruberMirjam Schenk
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sarah M ZaidanUNKNOWN Canadian HIV and Aging Cohort Study
Dec 17, 2020·International Journal of Molecular Sciences·Aleksander J Nowak, Borna Relja
Mar 13, 2021·Cellular & Molecular Immunology·Dan LiuYali Hu
May 14, 2021·Microbiology and Molecular Biology Reviews : MMBR·Maelig G MorvanJay A Levy
Jun 5, 2021·Nature Reviews. Cancer·Daria BriukhovetskaSebastian Kobold
Aug 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Silvia Galván-PeñaChristophe Benoist

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