Insights into the structure and function of membrane-integrated processive glycosyltransferases

Current Opinion in Structural Biology
Yunchen BiJochen Zimmer

Abstract

Complex carbohydrates perform essential functions in life, including energy storage, cell signaling, protein targeting, quality control, as well as supporting cell structure and stability. Extracellular polysaccharides (EPS) represent mainly structural polymers and are found in essentially all kingdoms of life. For example, EPS are important biofilm and capsule components in bacteria, represent major constituents in cell walls of fungi, algae, arthropods and plants, and modulate the extracellular matrix in vertebrates. Different mechanisms evolved by which EPS are synthesized. Here, we review the structures and functions of membrane-integrated processive glycosyltransferases (GTs) implicated in the synthesis and secretion of chitin, alginate, hyaluronan and poly-N-acetylglucosamine (PNAG).

References

Apr 5, 1978·Journal of Molecular Biology·R Minke, J Blackwell
Jul 1, 1991·The Journal of Cell Biology·J A ShawE Cabib
Jan 1, 1993·Annual Review of Microbiology·C E Bulawa
Dec 31, 1997·Science·P L DeAngelisJ L Van Etten
May 9, 1998·The Journal of Biological Chemistry·P L DeAngelisA M Achyuthan
Sep 25, 1998·The Journal of Biological Chemistry·V L Tlapak-SimmonsP H Weigel
Feb 5, 1999·Journal of Molecular Biology·J SugiyamaT Watanabe
Aug 24, 1999·The Journal of Biological Chemistry·N ItanoK Kimata
Oct 12, 2000·The Journal of Biological Chemistry·C HeldermonP H Weigel
Feb 5, 2002·Glycobiology·Paul L DeAngelis
Sep 14, 2002·Current Genetics·Cesar Roncero
Mar 26, 2003·The Journal of Biological Chemistry·Philip E Pummill, Paul L DeAngelis
Apr 19, 2003·FEMS Yeast Research·José Ruiz-HerreraRoberto Ruiz-Medrano
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Jul 14, 2004·Biochemistry·Valarie L Tlapak-SimmonsPaul H Weigel
Dec 30, 2004·The Journal of Biological Chemistry·Sabrina Bodevin-AutheletUlf Lindahl
Jan 26, 2005·The Journal of Biological Chemistry·Valarie L Tlapak-SimmonsPaul H Weigel
Aug 3, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hans Merzendorfer
Mar 9, 2006·The Biochemical Journal·Brian J GoentzelRobert A Steinberg
May 25, 2006·The Biochemical Journal·Peter Prehm
Jun 27, 2006·FEBS Letters·Uwe Remminghorst, Bernd H A Rehm
Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Oct 26, 2007·Metabolic Engineering·Huimin Yu, Gregory Stephanopoulos
Nov 6, 2007·The Journal of Biological Chemistry·Paul H Weigel, Paul L DeAngelis
Jun 4, 2008·Annual Review of Biochemistry·L L LairsonS G Withers
Oct 1, 2008·The Biochemical Journal·Fuensanta W Martínez-RucoboAnke C Terwisscha van Scheltinga
Oct 8, 2008·Nucleic Acids Research·Brandi L CantarelBernard Henrissat
May 12, 2009·Nucleic Acids Research·Andreas BernselArne Elofsson
Aug 29, 2009·Cell Cycle·Ee Mei TehFoong May Yeong
May 29, 2010·The Journal of Biological Chemistry·Eugenia KarousouParaskevi Heldin
Mar 3, 2011·The FEBS Journal·Raija H TammiMarkku I Tammi

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Citations

May 3, 2016·Assay and Drug Development Technologies·Thomas ZielinskiRobert G Lowery
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Pallinti PurushothamJochen Zimmer
Feb 25, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Haijian ZhangJiejie Xu
Dec 1, 2017·Glycobiology·Matthew R BlackburnJochen Zimmer
Oct 28, 2019·International Journal of Molecular Sciences·Luuk MestromPeter-Leon Hagedoorn
Jul 7, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ilaria CaonDavide Vigetti
Nov 24, 2017·Organic & Biomolecular Chemistry·Silvia BernardiFrancesco Sansone
Jul 11, 2020·Science·Pallinti PurushothamJochen Zimmer
Jan 12, 2021·Current Opinion in Structural Biology·Sean D Liston, Lisa M Willis
Nov 22, 2019·ACS Chemical Biology·Liubov Yakovlieva, Marthe T C Walvoort
Mar 9, 2021·Frontiers in Plant Science·Olga A ZabotinaRichard Weerts
Jun 14, 2021·Carbohydrate Polymers·Ushasree Mrudulakumari VasudevanEun Yeol Lee
Sep 12, 2018·Chemical Reviews·Nikos K KaramanosRenato V Iozzo

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