Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

Cancers
Lorenzo StramucciGianluca Bossi

Abstract

TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked to mutant p53 gain-of-function. In this review, we summarize the delicate relationship among p53 mutational status, MKK3/MKK6 and the downstream activated master kinase p38MAPK, dissecting a finely-tuned crosstalk, in a potentially cell-context dependent scenario that urges towards a deeper characterization of the different molecular players involved in this signaling cascade and their interactions.

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Citations

May 6, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wen-Qing ZhuJing Qiu
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Nov 7, 2019·Cell Death & Disease·Lorenzo StramucciGianluca Bossi
Apr 26, 2020·International Journal of Molecular Sciences·Chia-Liang LinChien-Min Chen
Apr 25, 2019·International Journal of Molecular Sciences·Malgorzata ZakrzewskaAntoni Wiedlocha
Apr 23, 2020·International Journal of Molecular Sciences·Angelina PrantedaGianluca Bossi
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