Insights on Heme Synthesis in the Malaria Parasite

Trends in Parasitology
Viswanathan Arun Nagaraj, Govindarajan Padmanaban

Abstract

The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme pool through multiple back-up mechanisms.

References

Jul 7, 2010·Molecular and Biochemical Parasitology·Viswanathan Arun NagarajGovindarajan Padmanaban
Jul 26, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jinglan ZhangChunli Yu
Feb 11, 2012·Antioxidants & Redox Signaling·Giel G van DoorenGeoffrey I McFadden
Sep 18, 2012·Trends in Parasitology·Marek CyrklaffMichael Lanzer

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Citations

Sep 29, 2017·PLoS Pathogens·Daniel E Goldberg, Paul A Sigala
Sep 26, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lina M OrregoJosé M Pérez-Victoria
Aug 6, 2020·International Journal of Molecular Sciences·Christiaan M SuttorpFrank A D T G Wagener
Mar 15, 2019·The Journal of Infectious Diseases·Fang-Fang LiuKe Li
Aug 25, 2021·MBio·Julie M J VerhoefTaco W A Kooij

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