INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma

Journal of Neuropathology and Experimental Neurology
Heather M AmesFausto J Rodriguez

Abstract

Tumors with a neuronal component comprise a small percentage of central nervous system (CNS) neoplasms overall, but the presence of neuronal differentiation has important diagnostic, prognostic, and therapeutic implications. Insulinoma-associated protein 1 (INSM1) is a transcription factor with strong nuclear immunostaining in neuroendocrine cells and neoplasms of neuroendocrine origin; however, its expression in the CNS in normal brain and in neoplastic cells has not been fully explored. Here, we present immunostaining results from a large number of archival CNS tissue specimens, including 416 tumors. Nuclear immunostaining for INSM1 was frequently seen in medulloblastomas (87%, n = 94). Diffuse nuclear INSM1 immunostaining was detected in all central neurocytomas and pituitary adenomas. Patchy to rare staining with INSM1 was also seen in other high-grade embryonal tumors and high-grade gliomas. In normal brain tissue, specific nuclear INSM1 immunohistochemical staining was only seen in early neuronal development. Notably, nuclear INSM1 staining was not seen in adult normal brain, including areas of gliosis. These findings indicate that nuclear INSM1 immunostaining may serve as a strong nuclear marker in the brain for neoplasm...Continue Reading

References

May 31, 2001·Journal of Neuropathology and Experimental Neurology·C G EberhartP C Burger
Jan 31, 2008·Neoplasia : an International Journal for Oncology Research·Enrico De SmaeleAlberto Gulino
Aug 22, 2008·Journal of Neuropathology and Experimental Neurology·Eli E BarCharles G Eberhart
Jan 27, 2011·Acta Neuropathologica·David W EllisonRichard J Gilbertson
Jun 15, 2011·Journal of Neuropathology and Experimental Neurology·Brent A OrrCharles G Eberhart
Nov 21, 2013·Acta Neuropathologica Communications·Maria LastowskaMichael S Jackson
Dec 19, 2014·Brain Pathology·Ulf D KahlertCharles G Eberhart
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Sep 20, 2015·American Journal of Clinical Pathology·Jason N RosenbaumRicardo V Lloyd
Oct 16, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Heather Marion AmesFausto J Rodriguez

❮ Previous
Next ❯

Citations

Apr 13, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Hannah WangGregory W Charville
Oct 26, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Katharina KriegsmannMark Kriegsmann
Mar 18, 2020·Journal of Neuropathology and Experimental Neurology·Satoshi NakataMeaghan Morris
May 23, 2019·Molecular Cancer Research : MCR·Chiachen ChenMichael S Lan
Jul 28, 2019·Journal of the American Society of Cytopathology : JASC·Kartik ViswanathanAlain C Borczuk
Feb 26, 2021·American Journal of Clinical Pathology·Maroa DridiGeorgia Karpathiou
Sep 24, 2020·Cellular Signalling·Chiachen Chen, Michael S Lan
May 22, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sylvia L AsaUNKNOWN Attendees of the 15th Meeting of the International Pituitary Pathology Club, Istanbul October 2019
Dec 17, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ching-Heng TingPao-Shu Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.