Insomnia cycling with a 42-day infradian period: evidence for two uncoupled circadian oscillators?

Sleep Medicine
Luca VignatelliPasquale Montagna

Abstract

To describe the unique case of a middle-aged woman with severe insomnia recurring with a regular infradian period without any other significant clinical condition. To infer the existence of a circadian dysfunction modeled according to the physical phenomenon of the "beats." A two-year prospective observation by means of a sleep log was performed during the patient's normal life. She underwent one month of motor activity recording and also polysomnography, circadian rhythm of body core temperature and psychiatric evaluation during periods with and without insomnia. Visual inspection of the 293-day plot of the sleep log disclosed a regular 42-day rhythm of insomnia recurrence confirmed by a Discrete Fourier Transform. During the periods of insomnia, lasting 5-7days, only moderate mood symptoms (depressive overlapping hypomaniac symptoms) were present. Treatment with sodium valproate was effective in curtailing insomnia. The wax and wane infradian modulation of the sleep length suggested the presence of a basic mechanism similar to the physical phenomenon of the "beats," i.e., a long period modulation of the amplitude of an oscillating system due to the interference of two uncoupled oscillators with a slightly different oscillatio...Continue Reading

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Feb 6, 2010·Sleep Medicine·Mark W MahowaldCarlos H Schenck
Nov 3, 2011·PloS One·Mark BlagroveOliver H Turnbull
May 17, 2018·Chronobiology International·Lucio Huebra Pimentel FilhoFernando Morgadinho Coelho
Jan 10, 2018·Nature Communications·Maxime O BaudVikram R Rao

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