Instability of different adolescent metabolic syndrome definitions tracked into early adulthood metabolic syndrome: Tehran Lipid and Glucose Study (TLGS)

Pediatric Diabetes
Golaleh AsghariFereidoun Azizi

Abstract

There are substantial controversies about the clinical utility of adolescent metabolic syndrome (MetS). The current study examined the stability of adolescent MetS by assessing the agreement and discriminative abilities of four different definitions of adolescent MetS and the adult MetS definition during a 10.4-yr follow up. For this study, 1424 adolescents (55.2% female), who participated in the framework of the Tehran Lipid and Glucose Study were included. Kappa was calculated for agreement between adolescent MetS definitions [Cook, de Ferranti, pediatric National Cholesterol Education Program (NCEP) and pediatric International Diabetes Federation (IDF)] and the adulthood MetS definition defined by the joint interim statement (JIS) criteria. MetS persistence, instability, and incidence were assessed, and for each of the four adolescent definitions, sensitivity, specificity, and area under receiver operating curve (AUC) for the counting of categorical adulthood MetS components was evaluated. The agreement between the four adolescent MetS definitions and JIS was poor (κ = 0.094-0.255). All definitions showed low sensitivity and high specificity, except for de Ferranti's, which contrary to other definitions, had higher sensitivi...Continue Reading

References

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Citations

Dec 26, 2018·International Journal of Endocrinology and Metabolism·Firoozeh Hosseini-EsfahaniFereidoun Azizi
Dec 26, 2018·International Journal of Endocrinology and Metabolism·Firoozeh Hosseini-EsfahaniFereidoun Azizi
Nov 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Carolin ReisingerNandu Goswami
Jun 3, 2021·Children·Valeria CalcaterraFatima Cody Stanford

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