Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice

Environmental Health Perspectives
Tobias StoegerHolger Schulz

Abstract

Increased levels of particulate air pollution are associated with increased respiratory and cardiovascular mortality and morbidity. Some epidemiologic and toxicologic research suggests ultrafine particles (UFPs) (< 100 nm) to be more harmful per unit mass than larger particles. Our study was aimed at a quantitative comparison of acute adverse effects of different types of carbonaceous UFPs at a dose range that causes a moderate inflammatory response in lungs. We used six different particle types (primary particle size 10-50 nm, specific surface area 30-800 m2/g, and organic content 1-20%): PrintexG, Printex90, flame soot particles with different organic content (SootL, SootH), spark-generated ultrafine carbon particles (ufCP), and the reference diesel exhaust particles (DEP) SRM1650a. Mice were instilled with 5, 20, and 50 microg of each particle type, and bronchoalveolar lavage was analyzed 24 hr after instillation for inflammatory cells and the level of proinflammatory cytokines. At respective mass-doses, particle-caused detrimental effects ranked in the following order: ufCP > SootL > or = SootH > Printex90 > PrintexG > DEP. Relating the inflammatory effects to the particle characteristics--organic content, primary particle ...Continue Reading

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Methods Mentioned

BETA
bronchoalveolar lavage
transmission electron microscopy
lavages
Protein Assay
lavage
enzyme-linked immunosorbent assays

Software Mentioned

Statgraphics

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