Institutional review of glial tumors treated with chemotherapy: the first description of PCV-related pseudoprogression

Neuro-oncology Practice
Ankur M SharmaMarshall Pitz

Abstract

Pseudoprogression refers to areas of enhancement on MRI postadjuvant chemoradiation that arise as a result of treatment-related effects. Pseudoprogression has been well described with temozolomide-based chemoradiation but has not been studied in the setting of procarbazine, lomustine, and vincristine (PCV) chemotherapy. We reviewed patients treated with PCV to investigate the occurrence of pseudoprogression. Adults diagnosed with World Health Organization grade II or III gliomas between 2010 and 2015 and treated with PCV or temozolomide were identified. Patient, tumor, treatment, and MRI data were retrospectively collected and analyzed. Pseudoprogression was defined as new enhancement seen on MRI within 6 months of completion of adjuvant radiotherapy or concurrent chemoradiation, which improved or remained stable on subsequent scans without therapeutic intervention. If MRI showed areas of new enhancement outside the 6-month post-treatment window, which resolved or remained stable without treatment, or in patients who did not receive adjuvant treatment, it was referred to as "atypical pseudoprogression." Fifty-seven patients were identified. Nine (16%) patients were identified as having pseudoprogression on MRI. Two (4%) of thes...Continue Reading

References

May 1, 1979·Journal of Neurosurgery·W F HoffmanC B Wilson
Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R MacdonaldJ G Cairncross
May 1, 1990·Annals of Neurology·D R MacdonaldJ G Cairncross
Apr 1, 1988·Annals of Neurology·J G Cairncross, D R Macdonald
Jun 6, 2006·Neuroradiology·Alfonso Di CostanzoGiocchino Tedeschi
Sep 1, 2006·Journal of Neuro-oncology·Marc C ChamberlainAndrew E Sloan
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent
Apr 8, 2009·Current Neurology and Neuroscience Reports·Jennifer L Clarke, Susan Chang
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
May 15, 2012·The Lancet Oncology·Wolfgang WickUNKNOWN NOA-08 Study Group of Neuro-oncology Working Group (NOA) of German Cancer Society
Jun 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Moritz StuplichUlrich Herrlinger
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Dec 5, 2012·Acta Neurologica Scandinavica. Supplementum·K M Knudsen-BaasA Storstein
Apr 7, 2016·The New England Journal of Medicine·Jan C BucknerWalter J Curran

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