Instructed Assembly as Context-Dependent Signaling for the Death and Morphogenesis of Cells

Angewandte Chemie
Huaimin WangBing Xu

Abstract

Context-dependent signaling is a ubiquitous phenomenon in nature, but ways to mimic the essence of these nano- and microscale dynamic molecular processes by noncovalent synthesis in the cellular environment have yet to be developed. Herein we present a dynamic continuum of noncovalent filaments formed by the instructed assembly (iA) of a supramolecular phosphoglycopeptide (sPGP) as context-dependent signals for controlling the death and morphogenesis of cells. Specifically, ectophosphatase enzymes on cancer cells catalyze the formation of sPGP filaments to result in cell death; however, damping of the enzyme activity induces the formation 3D cell spheroids. Similarly, the ratio of stromal and cancer cells in a coculture can be used to modulate the expression of the ectophosphatase, so that the iA process leads to the formation of cell spheroids. The spheroids mimic the tumor microenvironment for drug screening.

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Citations

Sep 12, 2019·Biomaterials Science·Qian WangJianfeng Liu
Apr 9, 2019·Chembiochem : a European Journal of Chemical Biology·Huaimin WangBing Xu
Aug 20, 2020·Chemical Reviews·Hongjian HeBing Xu
Jul 20, 2021·ACS Biomaterials Science & Engineering·Sung-Min KangShuichi Takayama
Apr 30, 2019·Journal of the American Chemical Society·Huaimin WangBing Xu

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