PMID: 9447497Feb 3, 1998Paper

Instrumental motor predictors of neuroleptic-induced parkinsonism in newly medicated schizophrenia patients

The Journal of Neuropsychiatry and Clinical Neurosciences
Michael P Caligiuri, J B Lohr

Abstract

Previous studies suggest that many untreated schizophrenia patients exhibit motor disturbances. On the basis of these findings, the authors hypothesized that preexisting extrapyramidal movement disorders may increase the risk of developing neuroleptic-induced parkinsonism (NIP). Thirty-five newly medicated psychotic patients underwent pretreatment clinical and instrumental motor and psychiatric assessments. Posttreatment ratings of parkinsonism were conducted at monthly intervals for the first 3 months and every 3 months thereafter. Thirteen patients (37%) developed NIP. Advanced age and pretreatment extrapyramidal disturbances predicted NIP. Life-table survival curves indicated that patients with pretreatment instrumental rigidity developed clinically significant NIP earlier than those without rigidity. These findings suggest that pretreatment motor dysfunction may be a risk factor for drug-induced parkinsonism, especially among older patients.

Citations

Nov 1, 2017·Current Psychiatry Reports·Sebastian Walther, Vijay A Mittal
Sep 8, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·T Scott Stroup, Neil Gray
Jun 4, 2008·Expert Opinion on Pharmacotherapy·Praveen Dayalu, Kelvin L Chou
Jun 20, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Burkhard Emanuel JabsBruno Pfuhlmann
May 1, 2004·Journal of Clinical Psychopharmacology·Charles E DeanSean M Nugent
Feb 20, 2021·The South African Journal of Psychiatry : SAJP : the Journal of the Society of Psychiatrists of South Africa·Francois-Pierre JoubertLaila Asmal
Jan 17, 2002·The Annals of Pharmacotherapy·I SchillevoortH G Leufkens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.