Insufficient CD100 shedding contributes to suppression of CD8+ T-cell activity in non-small cell lung cancer.

Immunology
Hong-Min WangFei-Fei Fan

Abstract

CD100 is an immune semaphorin constitutively expressed on T-cells. Matrix metalloproteinase (MMP) is an important mediator of membrane-bound CD100 (mCD100) cleavage to generate soluble CD100 (sCD100), which has immunoregulatory activity in immune cell responses. The aim of the study was to investigate the level and role of sCD100 and mCD100 in modulating CD8+ T-cell function in non-small cell lung cancer (NSCLC). sCD100 and MMP-14 levels in the serum and bronchoalveolar lavage fluid (BALF), and mCD100 expression on peripheral and lung-resident CD8+ T-cells were analysed in NSCLC patients. The ability to induce sCD100 and the effect of MMP-14 on mCD100 shedding for the regulation of non-cytolytic and cytolytic functions of CD8+ T-cells were also analysed in direct and indirect contact co-culture systems. NSCLC patients had lower serum sCD100 and higher mCD100 levels on CD8+ T-cells compared with healthy controls. BALF from the tumour site also had decreased sCD100 and increased mCD100 on CD8+ T-cells compared with the non-tumour site. Recombinant CD100 stimulation enhanced non-cytolytic and cytolytic functions of CD8+ T-cells from NSCLC patients, whereas blockade of CD100 receptor CD72 attenuated CD8+ T-cell activity. NSCLC pati...Continue Reading

References

Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·K T HallG J Freeman
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi KumanogohHitoshi Kikutani
Jan 6, 2007·The Journal of Biological Chemistry·John R BasileJ Silvio Gutkind
Jun 30, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M AtkinsonJ H Gill
Mar 25, 2014·Biochimica Et Biophysica Acta·Ilya UlasovCharles Cobbs
Jul 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Zhou WangZhi-Xiong Yang
Aug 20, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Sha-Sha RuanGang Wu
Feb 24, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Connie YipGary J R Cook
Dec 17, 2015·Advances in Experimental Medicine and Biology·Lindsey A TorreAhmedin Jemal
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang LiuJie Zhang
Jan 7, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kimia T MalekiNiklas K Björkström
Aug 9, 2016·Annual Review of Cell and Developmental Biology·Antonio Castro-CastroPhilippe Chavrier
Aug 25, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Svetlana P ChapovalElias Toubi
Dec 30, 2016·OncoTargets and Therapy·Ramon Andrade de MelloGeorgios Antoniou
Jul 1, 2017·Trends in Immunology·Chao WangAna C Anderson
Jul 18, 2017·Frontiers in Immunology·Xiaojun JiangEspen Melum
Sep 18, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Z VadaszZ Sthoeger
May 8, 2018·Molecular Cancer Therapeutics·Arthur WinerPaolo Mignatti
Jul 5, 2018·Frontiers in Endocrinology·Konstantinos LontosAttaya Suvannasankha
Jul 11, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hong-Min WangLin-Lin Guo
Oct 17, 2018·Frontiers in Cardiovascular Medicine·Maria C A LuqueBeatriz S Stolf
Oct 31, 2018·International Journal of Cancer. Journal International Du Cancer·Yun XiaGang Wu
Aug 6, 2019·Mayo Clinic Proceedings·Narjust DumaJulian R Molina
Nov 7, 2019·Biochemistry. Biokhimii︠a︡·E M Kuklina

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