Insufficient Humidification of Respiratory Gases in Patients Who Are Undergoing Therapeutic Hypothermia at a Paediatric and Adult Intensive Care Unit

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Yukari TanakaOsuke Iwata

Abstract

For cooled newborn infants, humidifier settings for normothermic condition provide excessive gas humidity because absolute humidity at saturation is temperature-dependent. To assess humidification of respiratory gases in patients who underwent moderate therapeutic hypothermia at a paediatric/adult intensive care unit, 6 patients were studied over 9 times. Three humidifier settings, 37-default (chamber-outlet, 37°C; Y-piece, 40°C), 33.5-theoretical (chamber-outlet, 33.5°C; Y-piece, 36.5°C), and 33.5-adjusted (optimised setting to achieve saturated vapour at 33.5°C using feedback from a thermohygrometer), were tested. Y-piece gas temperature/humidity and the incidence of high (>40.6 mg/L) and low (<32.9 mg/L) humidity relative to the target level (36.6 mg/L) were assessed. Y-piece gas humidity was 32.0 (26.8-37.3), 22.7 (16.9-28.6), and 36.9 (35.5-38.3) mg/L {mean (95% confidence interval)} for 37-default setting, 33.5-theoretical setting, and 33.5-adjusted setting, respectively. High humidity was observed in 1 patient with 37-default setting, whereas low humidity was seen in 5 patients with 37-default setting and 8 patients with 33.5-theoretical setting. With 33.5-adjusted setting, inadequate Y-piece humidity was not observed. P...Continue Reading

References

Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
May 15, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Bradley G CarterAnthony Osborne
Aug 13, 2003·Journal of Anesthesia·Hiroki WadaShinya Arimura
Jul 24, 2004·American Journal of Respiratory and Critical Care Medicine·François LelloucheLaurent Brochard
Jan 14, 2005·The New England Journal of Medicine·Michael M ToddUNKNOWN Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) Investigators
Jun 23, 2006·Intensive Care Medicine·François LelloucheLaurent Brochard
Aug 10, 2006·BMC Pulmonary Medicine·Daisuke InuiMasaji Nishimura
Mar 1, 2007·British Journal of Anaesthesia·S SchumannJ Guttmann
Sep 18, 2007·Journal of Critical Care·Paolo PelosiMaurizio Chiaranda
Jun 6, 2008·The New England Journal of Medicine·James S HutchisonUNKNOWN Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group
Mar 19, 2009·Intensive Care Medicine·François LelloucheLaurent Brochard
Oct 3, 2009·The New England Journal of Medicine·Denis V AzzopardiUNKNOWN TOBY Study Group
Nov 19, 2013·The New England Journal of Medicine·Niklas NielsenUNKNOWN TTM Trial Investigators
Aug 5, 2014·BioMed Research International·Haitham S Al Ashry, Ariel M Modrykamien
Jan 1, 2013·Journal of Intensive Care·Yusuke ChikataMasaji Nishimura
May 12, 2016·Therapeutic Hypothermia and Temperature Management·Shoichiro TanakaOsuke Iwata

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