Insular and occipital changes in visual snow syndrome: a BOLD fMRI and MRS study.

Annals of Clinical and Translational Neurology
Francesca PuleddaPeter J Goadsby

Abstract

To investigate the pathophysiology of visual snow (VS), through a combined functional neuroimaging and magnetic resonance spectroscopy (1 H-MRS) approach. We applied a functional MRI block-design protocol studying the responses to a visual stimulation mimicking VS, in combination with 1 H-MRS over the right lingual gyrus, in 24 patients with VS compared to an equal number of age- and gender-matched healthy controls. We found reduced BOLD responses to the visual stimulus with respect to baseline in VS patients compared to controls, in the left (k = 291; P = 0.025; peak MNI coordinate [-34 12 -6]) and right (k = 100; P = 0.003; peak MNI coordinate [44 14 -2]) anterior insula. Our spectroscopy analysis revealed a significant increase in lactate concentrations in patients with respect to controls (0.66 ± 0.9 mmol/L vs. 0.07 ± 0.2 mmol/L; P < 0.001) in the right lingual gyrus. In this area, there was a significant negative correlation between lactate concentrations and BOLD responses to visual stimulation (P = 0.004; r = -0.42), which was dependent on belonging to the patient group. As shown by our BOLD analysis, VS is characterized by a difference in bilateral insular responses to a visual stimulus mimicking VS itself, which could ...Continue Reading

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Citations

Jul 12, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C J SchankinP J Goadsby
Aug 8, 2020·Neurology·Francesca PuleddaPeter J Goadsby
Jan 14, 2021·Cephalalgia : an International Journal of Headache·Teresa Catarci
Jan 16, 2021·Human Brain Mapping·Francesca PuleddaPeter J Goadsby
Dec 18, 2020·Frontiers in Human Neuroscience·Njoud AldusaryLars Michels
Feb 23, 2021·Cephalalgia : an International Journal of Headache·Dev G MehtaCarrie E Robertson
May 13, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Robin M van DongenGisela M Terwindt
Jul 16, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Francesca PuleddaPeter J Goadsby

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Software Mentioned

Matlab script
Statistical Parametric Mapping
SPM
pickupatlas
SPSS
MATLAB
wfu

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