Insular variant of poorly differentiated thyroid carcinoma.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Ioana FatNancy J Rennert

Abstract

To present a case of an insular variant of poorly differentiated thyroid carcinoma (PDTC) and to review the literature related to diagnosis, natural history, and treatment of this unusual form of thyroid cancer. We present the clinical, laboratory, and pathologic findings of the study patient and review English-language literature related to PDTC published between 1970 and the present. PDTC is a controversial and rare epithelial thyroid cancer, intermediate between differentiated thyroid carcinoma and anaplastic thyroid carcinoma that exhibits increased aggressiveness, propensity to local recurrence, distant metastases, and increased mortality. PDTC warrants aggressive management with total thyroidectomy followed by radioactive iodine ablation and potentially additional therapy for residual or recurrent disease. Some carcinomas do not take up radioactive iodine, and dedifferentiated clones of distant metastases may evolve. It is unclear whether chemotherapy is beneficial. Use of additional imaging modalities, including positron emission tomography, 18-fludeoxyglucose positron emission tomography/computed tomography, 18-fludeoxyglucose positron emission tomography/computed tomography/magnetic resonance imaging, (124)I positron e...Continue Reading

References

Oct 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M SchlumbergerC Parmentier
Sep 1, 1984·The American Journal of Surgical Pathology·M L CarcangiuJ Rosai
Jan 1, 1995·Clinical Nuclear Medicine·I T ZakN J Gurll
May 1, 1993·Japanese Journal of Cancer Research : Gann·T ItoM Akiyama
Jan 15, 1994·Cancer·R AshfaqJ Albores-Saavedra
Sep 1, 1995·Pathology International·Y MizukamiM Hoso
Mar 1, 1996·European Journal of Nuclear Medicine·F GrünwaldH J Biersack
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J Fischman
Feb 1, 1997·The Laryngoscope·M W van den BrekelJ L Freeman
Apr 17, 1997·Nature·W Risau
Dec 31, 1997·The American Journal of Surgical Pathology·S PilottiF Rilke
Nov 11, 1998·Journal of the American College of Surgeons·J M RodriguezT Soria
Feb 16, 1999·The American Journal of Surgical Pathology·T NishidaH Matsuda
May 13, 1999·Thyroid : Official Journal of the American Thyroid Association·Y TakeuchiS Noguchi
Aug 24, 1999·Cancer·G E GuiterM F Zakowski
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·G ZettinigR Dudczak
Aug 31, 2000·The European Journal of Surgery = Acta Chirurgica·C Y LoK Y Wan
Dec 29, 2000·The Journal of Laryngology and Otology·I Ganly, J Crowther
Dec 18, 2001·Diagnostic Cytopathology·G K Nguyen, M R Akin
Apr 19, 2003·Clinical Nuclear Medicine·Berna DegirmenciRecep Bekis
Aug 31, 2006·Anti-cancer Drugs·Amalia MilanoFrancesco Caponigro
May 27, 2008·Endocrinology and Metabolism Clinics of North America·Zubair W Baloch, Virginia A LiVolsi
Jun 11, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vandana Gupta-AbramsonMarcia S Brose
Sep 4, 2008·Endocrine Pathology·Marco VolanteMauro Papotti
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard T KloosManisha H Shah
Aug 25, 2009·Advances in Anatomic Pathology·Massimo BongiovanniWilliam C Faquin
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Marco VolanteYuri E Nikiforov

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Citations

Sep 29, 2015·Cirugía española·Antonio RíosPascual Parrilla

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