Insulin: a novel factor in carcinogenesis

The American Journal of the Medical Sciences
K GuptaA N Peiris

Abstract

Cancer is a leading cause of mortality in the United States. Despite much research on specific carcinogens, the cause of many cancers remains unclear. The identification of novel causative agents offers the potential for cancer prevention. Diseases such as obesity and diabetes mellitus, characterized by hyperinsulinemia, are associated with increased risk of endometrial, colorectal, and breast carcinomas. There is increasing evidence that insulin is a growth factor for tumor formation. The mechanisms underlying insulin-mediated neoplasia may include enhanced DNA synthesis with resultant tumor cell growth, inhibition of apoptosis, and altered sex hormone milieu. The reduced insulin levels seen with physical activity, weight loss, and a high fiber diet may account for decreased cancer risk. The role of newer drugs that restore sensitivity to insulin, thereby reducing hyperinsulinemia, is an exciting potential area of cancer prevention. In this review, we discuss the potential role of insulin as a tumor growth factor.

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C K OsborneM E Lippman
Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·P F BruningW J Nooijen
Jul 1, 1992·Diabetes Care·M I HarrisM W Knuiman
Jun 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A GeierB Lunenfeld
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C La VecchiaS Franceschi
Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Sep 1, 1991·Cancer Causes & Control : CCC·H O AdamiI Persson
Jan 15, 1991·Cancer·E CersosimoM F Brennan
Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H Adlercreutz
Nov 1, 1990·The Journal of Clinical Investigation·V PapaR Vigneri
Jan 1, 1990·Critical Reviews in Oncology/hematology·D Albanes
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·R L Schilsky, F S Ordway
Dec 1, 1986·The Journal of Clinical Investigation·A N PeirisA H Kissebah
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J C Cohen, R Hickman
Jan 1, 1985·Journal of Chronic Diseases·B A O'MaraE Schoenfeld
Feb 1, 1967·Experimental Cell Research·J C HeusonR Heimann
Jun 15, 1982·Biochemical and Biophysical Research Communications·L Nagarajan, W B Anderson
Sep 4, 1995·International Journal of Cancer. Journal International Du Cancer·M KellererH U Häring
Mar 1, 1995·Cancer Causes & Control : CCC·E Giovannucci
Mar 1, 1995·Annals of Internal Medicine·E GiovannucciW C Willett
Dec 1, 1993·International Journal of Epidemiology·M MosesonB S Pasternack
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·P A Baghurst, T E Rohan
Feb 1, 1993·The Journal of Clinical Endocrinology and Metabolism·A N PeirisE Samols
Jan 1, 1993·Breast Cancer Research and Treatment·L FrittittaV Trischitta
Mar 27, 1996·Biochemical and Biophysical Research Communications·U BergmannM Korc
Jun 1, 1996·The Journal of Surgical Research·W E FisherW J Schirmer
Jul 12, 1996·Cancer Letters·D YamE Ben-Hur
Jan 1, 1996·Breast Cancer Research and Treatment·B A Stoll
Aug 1, 1996·Biochemical Society Transactions·M K el-Tanani, C D Green
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Vink-van WijngaardenJ P van Leeuwen
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·E WeiderpassH O Adami
Oct 6, 1997·Journal of the National Cancer Institute·L WideroffJ H Olsen
Mar 13, 1998·Breast Cancer Research and Treatment·M E Del GiudiceP J Goodwin

❮ Previous
Next ❯

Citations

Oct 24, 2009·Diabetologia·B Draznin
Jan 22, 2009·Biogerontology·Vladimir N AnisimovGraham Pawelec
Mar 7, 2008·Cancer Causes & Control : CCC·Yiting WangEugenia E Calle
Jan 24, 2009·The Annals of Thoracic Surgery·Paresh KamatSharmila Anandasabapathy
Nov 25, 2004·Best Practice & Research. Clinical Gastroenterology·Hugh J Freeman
May 8, 2004·Experimental Gerontology·Vladimir N AnisimovAnatoli I Yashin
Dec 12, 2003·Metabolism: Clinical and Experimental·Christina A FinlaysonBoris Draznin
Oct 7, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Loren CordainMary D Eades
Oct 1, 2005·Nature Reviews. Cancer·Vladimir N AnisimovAnatoly I Yashin
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Laura Vera-RamirezJose L Quiles
Jun 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P LagiouC La Vecchia
Aug 18, 2005·Journal of Gastroenterology and Hepatology·Ya-Yu WangWayne Huey-Herng Sheu
Jan 14, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachel L DerrStuart A Grossman
Dec 18, 2010·Magyar onkologia·Róbert János BánhegyiBéla Pikó
Oct 16, 2012·Recent Patents on Anti-cancer Drug Discovery·Zsuzsanna Suba
Oct 2, 2009·Future Oncology·Lloyd Balbuena, Alan G Casson
Dec 6, 2008·The American Journal of Clinical Nutrition·Wanqing WenWei Zheng
Feb 22, 2007·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jin GwackKeun-Young Yoo
Dec 18, 2013·Nutrition Reviews·Rita C R AlbuquerqueDirce M L Marchioni
Jan 23, 2013·Climacteric : the Journal of the International Menopause Society·H Kuhl, H P G Schneider
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P J VeugelersA G Casson
Jan 16, 2009·Diabetes/metabolism Research and Reviews·Doron WeinsteinHaim Werner
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Waka OhishiKazuaki Chayama
Feb 14, 2007·The American Journal of Medicine·Richard N BergmanMarilyn Ader
Jun 21, 2013·International Journal of Cancer. Journal International Du Cancer·Waka OhishiKazuaki Chayama
Aug 15, 2013·Diabetes, Obesity & Metabolism·T M Caparrotta, M Evans
Jun 19, 2010·ANZ Journal of Surgery·Zhanlong ShenYan Liu
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Irina G PopovichVladimir N Anisimov
Jun 29, 2004·Cancer Letters·Gacheri A KiungaRanjana P Bird
Aug 30, 2005·Experimental Gerontology·Vladimir N AnisimovClaudio Franceschi
Nov 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rafael B OrcyEdison Capp
May 30, 2015·Chinese Medical Journal·Shao Chin Lee, Juliana C N Chan
Nov 6, 2013·Cell Cycle·Vladimir N Anisimov
Feb 26, 2013·Critical Reviews in Oncology/hematology·Vladimir N Anisimov, Andrzej Bartke
Sep 10, 2014·International Journal of Food Sciences and Nutrition·Niki MouroutiDemosthenes B Panagiotakos
May 11, 2016·Pharmaceuticals·Panagiota PapanagnouMaria Tsironi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.