Insulin action on rates of muscle protein synthesis following eccentric, muscle-damaging contractions

Acta Physiologica Scandinavica
J D FluckeyH Galbo

Abstract

The purpose of this study was to determine whether eccentric, muscle-damaging contractions affect insulin action on muscle protein synthesis. Male Wistar rats (n = 28) were anaesthetized either once or twice separated by 7 days' rest, and one limb was electrically stimulated to contract eccentrically, while the contralateral limb served as a non-stimulated control. Twenty-four and 48 h after contractions, rates of protein synthesis were assessed in soleus and red or white gastrocnemius muscles during a hindlimb perfusion with or without insulin (20 000 microU mL(-1)). Rates of protein synthesis were not different in non-stimulated muscle, with or without insulin (P > 0.05). In red or white gastrocnemius without insulin, rates of protein synthesis were significantly reduced (P < 0.05) 24 and 48 h after a single session and 48 h after a double session of muscle contractions. However, protein synthesis was normalized with insulin 24 and 48 h after contractions in red, and 48 h after contractions in white gastrocnemius. In soleus muscle, protein synthesis was impaired only 48 h after the second session, but partially restored by insulin (P < 0.05). These results indicate that muscle becomes more sensitive to insulin action on rates...Continue Reading

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Citations

Apr 16, 2009·American Journal of Physiology. Endocrinology and Metabolism·Heath G GasierJames D Fluckey
Aug 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·James D FluckeyCharlotte A Peterson
Dec 1, 2012·British Journal of Sports Medicine·Thomas M BestJohnny Huard
Oct 17, 2013·Postgraduate Medical Journal·Thomas M BestJohnny Huard
Oct 28, 2004·American Journal of Physiology. Endocrinology and Metabolism·Chad C CarrollTodd A Trappe

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