Insulin-activated amiloride-blockable nonselective cation and Na+ channels in the fetal distal lung epithelium

General Pharmacology
H Tohda, Y Marunaka

Abstract

1. The apical membrane of fetal distal lung epithelium had two types of amiloride-blockable Na(+)-permeant cation channels; (1) nonselective cation (NSC) channel with a single channel conductance of 27 pS and (2) Na+ channel with a single channel conductance of 12 pS around resting membrane potential. 2. The IC50 of amiloride to the Na+ channel was 1-2 microM, while the IC50 of amiloride to the NSC channel was less 1 microM. The open probability of the Na+ channel was about 10-fold larger than that of the NSC channel. 3. Insulin (100 nM) increased the open probability of both channels.

References

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Citations

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·R A ShimketsC M Canessa
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·D E SmithH M O'Brodovich
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rachel L Zemans, Michael A Matthay
Nov 17, 2007·Respiratory Physiology & Neurobiology·S M WilsonD V Walters
Feb 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eleftheria IeronymakiChristos Tsatsanis
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xi-Juan ChenLucky Jain

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