PMID: 11921426Mar 29, 2002Paper

Insulin analogues: have they changed insulin treatment and improved glycaemic control?

Diabetes/metabolism Research and Reviews
Sten Madsbad

Abstract

To improve insulin therapy, new insulin analogues have been developed. Two fast-acting analogues with a more rapid onset of effect and a shorter duration of action combined with a low day-to-day variation in absorption rate are now available. Despite this favourable time-action profile most studies have not been able to show any improvement in overall glycaemic control with the fast-acting analogues. A reduced post-prandial increase in blood glucose has been found in all studies, whereas between 3 and 5 h after the meal and during the night an increased blood glucose level is the normal course. This is probably the main explanation for the absence of improvement in overall glycaemic control when compared with regular human insulin. A tendency to a reduction in hypoglycaemic events during treatment with fast-acting analogues has been observed in most studies. Recent studies have indicated that NPH insulin administered several times daily at mealtimes can improve glycaemic control without increasing the risk of hypoglycaemia. The fast-acting analogues are now also available as insulin mixed with NPH. Insulin glargine is a new long-acting insulin which is soluble and precipitates after injection, resulting in a long half-life with...Continue Reading

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Citations

May 18, 2010·Diabetes Technology & Therapeutics·Keizo FukushimaKanji Takada
Jun 2, 2007·Journal of Drug Targeting·Yukako ItoKanji Takada
Jul 18, 2006·The American Journal of the Medical Sciences·Jack L Leahy
Apr 7, 2005·Fundamental & Clinical Pharmacology·Jørgen RungbyOle Schmitz
Dec 25, 2004·Diabetes/metabolism Research and Reviews·Riccardo SchiaffiniAntonino Crinó
Aug 22, 2006·Metabolism: Clinical and Experimental·Marc S Rendell, Lois Jovanovic
Nov 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vijay K YechoorC Ronald Kahn
Dec 25, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Antonio NicolucciMarco Orsini Federici

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