PMID: 16502970Mar 1, 2006Paper

Insulin and arterial hypertension: the role of the kidney

Bulletin et mémoires de l'Académie royale de médecine de Belgique
Renaud Beauwens

Abstract

We have demonstrated that insulin stimulates sodium reabsorption in the distal nephron by stimulating the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and that any stimulation of this enzyme (e.g. by EGF, by H2O2 or by exogenous PIP3, added apically) leads to a parallel increase in sodium reabsorption. We therefore suggest that hyperinsulinemia leads to hypertension through increased renal sodium reabsorption in the distal nephron.

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