Insulin and glucagon secretion by ganglionic nicotinic activation in adrenalectomized mice

European Journal of Pharmacology
S Karlsson, B Ahrén

Abstract

The pancreatic islets are innervated by nerves emanating from intra- and extrapancreatic ganglia. However, the effects of ganglionic activation on insulin and glucagon release in vivo have not been established. We therefore investigated the effects of pharmacological ganglionic activation by the nicotinic agonists DMPP (1,1-dimethyl-4-phenylpiperazinium iodide) and nicotine on insulin and glucagon release in sham-operated and adrenalectomized mice. In sham-operated animals, DMPP (0.5 or 1.6 micromol/kg, i.v.) or nicotine (0.075 or 0.75 micromol/kg, i.v.), did not affect plasma insulin levels, but markedly increased plasma glucagon levels (P < 0.05). In contrast, after adrenalectomy or alpha2-adrenoceptor blockade by yohimbine (3.6 micromol/kg), nicotinic activation markedly increased plasma insulin levels (P < 0.05), whereas the glucagon response to nicotinic activation was inhibited under these conditions (P < 0.05). We conclude that pharmacological ganglionic nicotinic activation in mice stimulates insulin and glucagon secretion. The insulinotropic effect is, however, counteracted by a concomitant adrenal activation through an alpha2-adrenoceptor-mediated mechanism.

References

Jul 1, 1991·Molecular and Cellular Endocrinology·A DebuyserJ C Henquin
Mar 1, 1990·Diabetes Research and Clinical Practice·K EjiriS Baba
Mar 1, 1991·Journal of the Autonomic Nervous System·S Karlsson, B Ahrén
Feb 1, 1986·Clinics in Endocrinology and Metabolism·E SamolsG C Weir
Nov 3, 1987·European Journal of Pharmacology·G SkoglundB Ahrén
May 1, 1988·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Dec 1, 1986·Acta Physiologica Scandinavica·B Ahrén, I Lundquist
Apr 24, 1981·European Journal of Pharmacology·B Ahrén, I Lundquist
Jan 1, 1982·Pharmacology·I Lundquist

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Citations

Mar 21, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph L Borowitz, Gary E Isom
Oct 26, 2018·Nature Communications·Christoffer ClemmensenMatthias H Tschöp
Mar 8, 2019·Frontiers in Neuroscience·Wenjing LiLei Sha
Jan 11, 2020·Endocrinology, Diabetes & Metabolism·Marie-Béatrice SaadeSophie Blat

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