PMID: 6987674Feb 1, 1980Paper

Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers

Proceedings of the National Academy of Sciences of the United States of America
D L BrautiganE H FISCHER


Calcium uptake by skinned muscle fibers is stimulated by physiological concentrations of insulin. These fibers, which lack a functional plasma membrane, are permeable to macromolecules but retain extensive portions of their sarcolemma in the form of transverse tubules intercalated between the myofibrils. They have an active sarcoplasmic reticulum that removes 45Ca2+ from solution at concentrations below the threshold that initiates contraction (less than 1 microM). The Ca2+ uptake activity is stimulated by insulin, presumably in response to its binding to those receptors located in the transverse tubules. Addition of glucose 6-phosphate, whose intracellular concentration increases in response to insulin, also stimulates Ca2+ uptake, a unique property of this preparation. These data indicate that insulin and glucose 6-phosphate act in concert to stimulate the sarcoplasmic reticulum. The resulting decrease in myoplasmic Ca2+ and the increase in glucose 6-phosphate would serve to mediate some of the anabolic effects of the hormone.


Jul 18, 1978·Pflügers Archiv : European journal of physiology·J Y Su, W G Kerrick
May 15, 1979·Pflügers Archiv : European journal of physiology·J Y Su, W G Kerrick
Jul 12, 1976·Biochemical and Biophysical Research Communications·J M McDonaldL Jarett
Jul 8, 1977·Biochimica Et Biophysica Acta·F Eckstein
Feb 1, 1974·Science·W G Kerrick, P M Best
Aug 1, 1971·Journal of Neurochemistry·I Diamond, A L Goldberg
Jul 12, 1972·Biochimica Et Biophysica Acta·W G Kerrick, S K Donaldson
Jun 1, 1965·The Journal of Cell Biology·L D Peachey


Sep 1, 1980·Pflügers Archiv : European journal of physiology·P S CassidyW G Kerrick
Jan 1, 1989·General Pharmacology·V M AltanA T Ozçelikay
Mar 21, 1983·Biochimica Et Biophysica Acta·R D Moore
Jun 20, 2001·Acta Physiologica Scandinavica·J D BrutonH Westerblad
Sep 1, 1984·The American Journal of Physiology·A KlipW J Logan

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