Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study

Pediatric Blood & Cancer
Danielle Novetsky FriedmanCharles A Sklar

Abstract

Childhood cancer survivors exposed to abdominal radiation (abdRT) are at increased risk for both insulin-dependent and non-insulin-dependent diabetes. We sought to clarify the pathophysiology of diabetes after abdRT by performing dynamic studies of insulin and glucose and testing for type 1 diabetes-associated autoantibodies. Cross-sectional analysis of 2-year childhood cancer survivors treated with abdRT at age ≤21 years who underwent oral glucose tolerance testing and assessment of diabetes-related autoantibodies from December 2014 to September 2016. Prevalence of insulin/glucose derangements, indices of insulin sensitivity/secretion (homeostatic model assessment of insulin resistance [HOMA-IR], whole-body insulin sensitivity, insulinogenic index), autoantibody positivity, and treatment/demographic factors associated with adverse metabolic outcomes were assessed. Among 40 participants previously exposed to abdRT (57.5% male; median age at cancer diagnosis, 3.3 years [range, 0.5-20.1]; median age at study 14.3 years [range, 8.3-49.8]; none with obesity), 9 (22.5%) had glucose derangements (n = 4 with impaired fasting glucose [≥100 mg/dL]; n = 4 with impaired glucose tolerance [2-hour glucose 140-199 mg/dL]; n = 1 with previous...Continue Reading

References

Sep 2, 1995·Lancet·C TeinturierJ Timsit
May 20, 1999·Diabetes Care·A L RosenbloomW E Winter
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Catherine W YeckelSonia Caprio
Jun 29, 2004·Diabetes Care·George AlbertiUNKNOWN Consensus Workshop Group
Feb 17, 2005·Pediatric Blood & Cancer·Caroline LaverdièreCharles A Sklar
Nov 25, 2005·Diabetes·Catherine PihokerAke Lernmark
Jan 8, 2008·Autoimmunity·Craig E Taplin, Jennifer M Barker
Jul 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin C OeffingerGloria Lena Vega
Jul 1, 2010·Diabetes Care·Ralph A DeFronzo, Masafumi Matsuda
Feb 15, 2011·Pediatric Blood & Cancer·Thomas PerweinChristian Urban
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Aug 28, 2012·The Lancet Oncology·Kevin C Oeffinger, Charles A Sklar
Feb 8, 2013·Journal of Pediatric Hematology/oncology·Marjolein van WaasMarry M van den Heuvel-Eibrink
Mar 19, 2013·Journal of the American College of Cardiology·Michael KhouryBrian W McCrindle
Feb 11, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna Sällfors HolmqvistUNKNOWN ALiCCS study group
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederika A van NimwegenFlora E van Leeuwen
Sep 25, 2014·Pediatric Blood & Cancer·Mark A ApplebaumSusan L Cohn
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navin R PintoSusan L Cohn
Jul 7, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sogol Mostoufi-MoabCharles A Sklar
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association
Dec 30, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mark A ApplebaumSharon J Diskin

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Citations

Jul 23, 2019·Journal of the National Cancer Institute·Danielle Novetsky FriedmanCharles A Sklar
Oct 16, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Sophie WelschPhilippe A Lysy
Jan 17, 2019·Hormone Research in Pædiatrics·Danielle Novetsky FriedmanPaul Cohen

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