PMID: 6164587May 1, 1981Paper

Insulin and its secretagogues activate Ca2+-dependent phosphatidylinositol breakdown and amylase secretion in rat pancreas in vitro

Diabetes
R V FareseM A Sabir

Abstract

We studied the effects of insulin and insulin secretagogues on pancreatic phospholipids and the release of amylase from pancreatic fragments incubated in vitro. Insulin provoked rapid, dose-related increases in amylase release, and these were accompanied by decreases in phosphatidylinositol and increases in phosphatidic acid. Glucose and other insulin secretagogues elicited similar changes in amylase release and pancreatic phospholipids; epinephrine blocked these effects of glucose, presumably via inhibition of glucose-induced insulin secretion. Effects of insulin and glucose on phospholipids and amylase release were dependent on Ca2+ in the incubation medium. These findings suggest that, in the pancreas, insulin enhances Ca2+-dependent phosphatidylinositol breakdown, which in turn influences amylase secretion. The effects of insulin on phospholipids may also explain certain other actions of insulin.

Citations

Apr 1, 1984·Molecular and Cellular Endocrinology·R V Farese
Jun 1, 1984·Molecular and Cellular Endocrinology·B Koepfer-Hobelsberger, O H Wieland
Jul 1, 1983·The Journal of Clinical Investigation·K V AxenN Fleischer
Apr 19, 2011·Cardiovascular Diabetology·Kei NakajimaHiromi Munakata
Feb 1, 1986·European Journal of Clinical Investigation·J SkrhaV Pacovský
May 1, 1985·Journal of Cellular Physiology·E J Kasambalides, K W Lanks
Aug 1, 1983·Archives of Biochemistry and Biophysics·S L MacaulayL Jarett
Oct 1, 1994·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J von SchönfeldM K Müller

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