PMID: 11314683Apr 21, 2001Paper

Insulin and leptin levels in patients with schizophrenia or related psychoses--a comparison between different antipsychotic agents

Psychopharmacology
K Melkersson, A L Hulting

Abstract

Conventional as well as newer antipsychotics cause weight gain, and, in the regulation of body weight, both insulin and leptin are hormones involved. The aim of the present study was to compare these hormonal levels in patients on treatment with different antipsychotics. Nineteen patients receiving conventional antipsychotics, 14 patients receiving clozapine and 14 patients receiving olanzapine, were studied. Fasting blood samples for insulin, leptin, glucose, and drug serum concentrations were analyzed. In addition, body mass index (BMI) was calculated. The median insulin level was significantly higher in the patients receiving olanzapine than in those receiving conventional agents, whereas there was no significant difference in insulin between the clozapine and the other two groups. However, in the clozapine group, insulin levels were positively correlated to the drug serum concentration. BMI was elevated in about half of the patients, with no difference being found between the groups. The leptin level was significantly higher in the women than in the men in the conventional agent group, but not in the olanzapine or clozapine groups. The higher insulin level in the patients receiving olanzapine than in those receiving convent...Continue Reading

Citations

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