Insulin and sex interactions in older adults with mild cognitive impairment.

Journal of Alzheimer's Disease : JAD
Brenna CholertonSuzanne Craft

Abstract

Alzheimer's disease (AD) and other dementias are likely preceded by a protracted preclinical state. Thus, identification of biomarkers that signal potential points of intervention during this prodromal phase (during which patients are largely able to compensate for their cognitive deficits) is of paramount importance. Insulin is a pancreatic hormone with potent central nervous system effects, and insulin dysregulation has been implicated in the pathogenesis of both AD and vascular dementia. The aim of the current study was to determine whether circulating insulin differs as a function of mild cognitive impairment (MCI) diagnosis, and whether this relationship is mediated by sex and apolipoprotein E (APOE) genotype. A sample of 549 nondemented participants aged 65 and over from the Adult Changes in Thought community-based cohort underwent cognitive testing and blood draw to determine fasting levels of plasma insulin. Subjects were categorized as having normal cognitive functioning, amnestic MCI, or nonamnestic MCI. Results showed that the relationship between insulin and diagnostic category is moderated by sex, such that men with nonamnestic or amnestic MCI have higher fasting plasma insulin than cognitively normal men, while wo...Continue Reading

Citations

Mar 9, 2013·Advances in Physiology Education·Denovan P Begg, Stephen C Woods
Oct 4, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Jun 5, 2015·Translational Stroke Research·Vasileios-Arsenios LioutasVera Novak

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